Bok debut for Lions prop
Dreyer, who will become Springbok number 886 when he takes to the field, replaces Frans Malherbe in the front row in one of two changes to the starting pack that defeated the French team last week in Durban.
The other change is at flank as Teboho Mohoje is unavailable after he took a blow to the head last week. His place is filled by 21-year-old Jean-Luc du Preez, who came on as the replacement flank at Kings Park. Jaco Kriel has been selected on the bench.
In the backline, Francois Hougaard replaces Ross Cronje, who was not considered after he had shown symptoms of a delayed concussion. This will be Hougaard's 42nd Test cap for the Springboks, while Rudy Paige comes into the squad as replacement No 9.
The only other change to the starting team is at outside centre, with Jesse Kriel back after sitting out last week's Test a result of a bump to the head in the first match two weeks ago in Pretoria.
"I said earlier in the week that we would keep changes in the starting team to a minimum because we have huge respect for this powerful French side," said Bok head coach Allister Coetzee.
"The inclusion of Ruan [Dreyer] in the starting team gives us an important opportunity to build capacity in the tighthead position. This is a very important position and it is great to have players such as Coenie Oosthuizen and Steven Kitshoff coming off the bench as a combination, while Ruan will start next to his Lions hooker in Malcolm Marx.
"The same applies for Jaco Kriel, who has fully recovered from his knee injury and he was very good in training the past three weeks. He deserves his chance in the match 23 and he is very eager to play. Jaco was in brilliant form before he got injured and I am sure he will make a huge impact off the bench.
"Jesse [Kriel] had an outstanding game in the first match in Pretoria and he really combined well with Jan Serfontein in the midfield before he was forced to leave the field. The retention of combinations is important because that will add to our continuity.
"The selection of the centre pairing was really a tough task and Lionel Mapoe is perhaps unlucky to lose out in the match 23. He played well in Durban, but Jesse was also very good next to Jan Serfontein in Pretoria and my decision is based on developing combinations. Lionel will, however, get the opportunity to play for the SA A' side against the French Barbarians on Friday in Soweto."
Coetzee once more cautioned his side to expect a huge onslaught from the French: "Their camp is clear about it and the players realise there is no place for complacency.
"This is their last match of the season and they will be highly motivated to finish on a high, so they will yet again pose a serious threat. We will have to work extremely hard against a very physical French side who will again test us in all departments," said Coetzee.
South Africa: 15 Andries Coetzee, 14 Raymond Rhule, 13 Jesse Kriel, 12 Jan Serfontein, 11 Courtnall Skosan, 10 Elton Jantjies, 9 Francois Hougaard, 8 Warren Whiteley, 7 Jean-Luc du Preez, 6 Siyamthanda Kolisi, 5 Francois Mostert, 4 Eben Etzebeth, 3 Ruan Dreyer, 2 Malcolm Marx, 1 Tendai Mtawarira.
Replacements: 16 Mbongeni Mbonambi, 17 Steven Kitshoff, 18 Coenraad Oosthuizen, 19 Pieter-Steph du Toit, 20 Jaco Kriel, 21 Rudy Paige, 22 Francois Steyn, 23 Dillyn Leyds.
Date: Saturday, June 24
Venue: Ellis Park, Johannesburg
Kick-off: 17.00 (17.00 France time; 15.00 GMT)
Referee: Angus Gardner (Australia)
Assistant referees: Ben O'Keeffe (New Zealand), Glen Jackson (New Zealand)
TMO: Rowan Kitt (England)
