Uruguay change two for England date
Felipe Berchesi replaces Alejo Durán at flyhalf and Mateo Sanguinetti steps in for Alejo Corral at loosehead prop.
Two is the second fewest changes Uruguay have made between successive World Cup matches.
Los Teros made only one change in 1999 to the side that had beaten Spain and faced Scotland.
Agustín Ormaechea has been cleared to play against England following his red card (resulting from two yellows) against Fiji.
Ormaechea's was the first dismissal at the 2015 World Cup and the first by a Uruguay player in a World Cup match.
Alejo Corral will make his 50th Test appearance for Uruguay should he come on as a replacement.
Manuel Blengio is the only player in Uruguay's squad who has not yet played at World Cup 2015.
He will make his World Cup debut if he comes off the bench.
Uruguay: 15 Gaston Mieres, 14 Santiago Gibernau, 13 Joaquin Prada, 12 Andres Vilaseca, 11 Rodrigo Silva, 10 Felipe Berchesi, 9 Agustin Ormaechea, 8 Alejandro Nieto, 7 Matias Beer, 6 Juan Manuel Gaminara, 5 Jorge Zerbino, 4 Santiago Vilaseca (captain), 3 Mario Sagario, 2 Carlos Arboleya, 1 Mateo Sanguinetti.
Replacements: 16 Nicolas Klappenbach, 17 Oscar Duran, 18 Alejo Corral, 19 Mathias Palomeque, 20 Diego Magno, 21 Agustin Alonso, 22 Alejo Duran, 23 Manuel Blengio.
Date: Saturday, October 10
Venue: Manchester City Stadium, Manchester
Kick-off: 20.00 (19.00 GMT, 16.00 Uruguay time)
Referee: Chris Pollock (New Zealand)
Assistant referees: Angus Gardner (Australia), Federico Anselmi (Argentina)
TMO: George Ayoub (Australia)
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