England face Pumas without Farrell and Itoje
England face Pumas without Farrell and ItojeSHARE
The duo are being rested this week as part of head coach Eddie Jones' long-term plan to keep players fresh.
Seven players – Mike Brown, George Ford, Dylan Hartley, Nathan Hughes, Chris Robshaw, Henry Slade and Sam Underhill – who started in England's last Test against Argentina in June retain their place this weekend.
Elliot Daly will start on the left wing after Jonny May did not recover in time from his hamstring injury.
Daly is joined by Dan Cole, Courtney Lawes, Mako Vunipola and Anthony Watson who all last played for England during the successful 2017 Six Nations campaign.
"As a squad we have been preparing for this game since our first camp in August and are excited about playing in front of 82 000 fans at Twickenham Stadium on Saturday," Jones said.
"This is our best 23 selected in what is our most important game this year. We know that Argentina is a strong team – Rugby World Cup semifinalists in 2015 – and we will have to be smart and play well to beat them."
England: 15 Mike Brown, 14 Anthony Watson, 13 Jonathan Joseph, 12 Henry Slade, 11 Elliot Daly, 10 George Ford, 9 Ben Youngs, 8 Nathan Hughes, 7 Sam Underhill, 6 Chris Robshaw, 5 George Kruis, 4 Courtney Lawes, 3 Dan Cole, 2 Dylan Hartley (captain), 1 Mako Vunipola.
Replacements: 16 Jamie George, 17 Ellis Genge, 18 Harry Williams, 19 Joe Launchbury, 20 Tom Curry, 21 Danny Care, 22 Alex Lozowski, 23 Semesa Rokoduguni.
Date: Saturday, November 11
Venue: Twickenham, London
Kick-off: 15.00 (15.00 GMT; 12.00 Argentina Time)
Referee: Marius van der Westhuizen (South Africa)
Assistant referees: Nigel Owens (Wales), Dan Jones (Wales)
TMO: Olly Hodges (Ireland)