Former King Parkes to face against Boks
Scarlets' New Zealand-born centre Hadleigh Parkes will make his Test debut with scrumhalf Aled Davies the other change in the backline. Parkes previously played for the Blues, Southern Kings and the Hurricanes in Super Rugby.
Parkes will partner Scott Williams in the centre with Davies lining up alongside Dan Biggar at halfback. Leigh Halfpenny, Steff Evans and Hallam Amos feature in an unchanged back three.
There are three changes in the pack with Kristian Dacey and Scott Andrews coming into the front row alongside Rob Evans. Lock Cory Hill packs down alongside captain Alun Wyn Jones and it is an unchanged back row of Aaron Shingler, Josh Navidi and Taulupe Faletau.
"Saturday is an opportunity to continue to build on what we have done so far and round off the autumn campaign with a big performance," said Wales head coach Warren Gatland.
"We have spoken about exposing the squad to Test match rugby and this weekend is a great opportunity for Hadleigh to earn his first cap and for Aled to make his first start of the campaign.
"We have had a couple of knocks from last weekend, with Ken [Owens], Leon [Brown] and Jake [Ball] unavailable but that just provides an opportunity for Kristian, Scott and Cory to start."
Elliot Dee, Wyn Jones and Rhodri Jones (who linked up with the squad on Monday) provide the front row cover. Seb Davies and Dan Lydiate complete the forward contingent. Rhys Webb, Rhys Patchell and Owen Watkin are the backline cover.
Wales: 15 Leigh Halfpenny, 14 Hallam Amos, 13 Scott Williams, 12 Hadleigh Parkes, 11 Steff Evans, 10 Dan Biggar, 9 Aled Davies, 8 Taulupe Faletau, 7 Josh Navidi, 6 Aaron Shingler; 5 Alun Wyn Jones (captain), 4 Cory Hill, 3 Scott Andrews, 2 Kristian Dacey, 1 Rob Evans.
Replacements: 16 Elliot Dee, 17 Wyn Jones, 18 Rhodri Jones, 19 Seb Davies, 20 Dan Lydiate, 21 Rhys Webb, 22 Rhys Patchell, 23 Owen Watkin.
Date: Saturday, December 2
Venue: Millennium Stadium, Cardiff
Kick-off: 14.30 (14.30 GMT; 16.30 SA Time)
Referee: Jérôme Garcès (France)
Assistant referees: Wayne Barnes (England), Frank Murphy (Ireland)
TMO: Rowan Kitt (England)