| | FIXTURE | VENUE | GMT | LOCAL | POOL |
| | Fri, 17 September 2021 |
| | Bristol v Saracens | Ashton Gate | 18:45 | 20:45 | Round 1 |
| |
| | Sat, 18 September 2021 |
| | London Irish v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 1 |
| | Exeter Chiefs v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 1 |
| | Gloucester v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 1 |
| | Bath v Sale Sharks | AJ Bell Stadium | 16:00 | 18:00 | Round 1 |
| |
| | Sun, 19 September 2021 |
| | Harlequins v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 1 |
| |
| | Fri, 24 September 2021 |
| | Gloucester v Leicester Tigers | Kingsholm Stadium | 18:45 | 20:45 | Round 2 |
| |
| | Sat, 25 September 2021 |
| | Bath v Newcastle Falcons | Recreation Ground | 14:00 | 16:00 | Round 2 |
| | Exeter Chiefs v Northampton Saints | Sandy Park Stadium | 14:00 | 16:00 | Round 2 |
| | Harlequins v Worcester Warriors | Twickenham Stoop | 14:00 | 16:00 | Round 2 |
| | Bristol v Wasps | TBC | 14:00 | 16:00 | Round 2 |
| |
| | Sun, 26 September 2021 |
| | London Irish v Sale Sharks | Community Stadium | 14:00 | 16:00 | Round 2 |
| |
| | Fri, 1 October 2021 |
| | Bath v Bristol | Ashton Gate | 18:45 | 20:45 | Round 3 |
| |
| | Sat, 2 October 2021 |
| | London Irish v Northampton Saints | Franklins Gardens | 13:00 | 15:00 | Round 3 |
| | Leicester Tigers v Saracens | TBC | 14:00 | 16:00 | Round 3 |
| | Newcastle Falcons v Wasps | Kingston Park | 14:00 | 16:00 | Round 3 |
| | Gloucester v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 3 |
| |
| | Sun, 3 October 2021 |
| | Exeter Chiefs v Sale Sharks | AJ Bell Stadium | 14:00 | 16:00 | Round 3 |
| |
| | Fri, 8 October 2021 |
| | Bristol v Harlequins | Twickenham Stoop | 18:45 | 20:45 | Round 4 |
| |
| | Sat, 9 October 2021 |
| | Newcastle Falcons v Saracens | TBC | 14:00 | 16:00 | Round 4 |
| | Leicester Tigers v London Irish | Community Stadium | 14:00 | 16:00 | Round 4 |
| | Exeter Chiefs v Worcester Warriors | Sandy Park Stadium | 14:00 | 16:00 | Round 4 |
| | Gloucester v Sale Sharks | Kingsholm Stadium | 14:00 | 16:00 | Round 4 |
| |
| | Sun, 10 October 2021 |
| | Northampton Saints v Wasps | TBC | 14:00 | 16:00 | Round 4 |
| |
| | Fri, 15 October 2021 |
| | Harlequins v Sale Sharks | AJ Bell Stadium | 18:45 | 20:45 | Round 5 |
| |
| | Sat, 16 October 2021 |
| | Bristol v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 5 |
| | Exeter Chiefs v Wasps | TBC | 14:00 | 16:00 | Round 5 |
| | Leicester Tigers v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 5 |
| |
| | Sun, 17 October 2021 |
| | Bath v Saracens | Recreation Ground | 14:00 | 16:00 | Round 5 |
| | Gloucester v London Irish | Community Stadium | 14:00 | 16:00 | Round 5 |
| |
| | Fri, 22 October 2021 |
| | Northampton Saints v Worcester Warriors | Franklins Gardens | 18:45 | 20:45 | Round 6 |
| |
| | Sat, 23 October 2021 |
| | Gloucester v Newcastle Falcons | Kingsholm Stadium | 14:00 | 16:00 | Round 6 |
| | Bath v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 6 |
| | Leicester Tigers v Sale Sharks | TBC | 14:00 | 16:00 | Round 6 |
| | Exeter Chiefs v London Irish | Sandy Park Stadium | 14:00 | 16:00 | Round 6 |
| |
| | Sun, 24 October 2021 |
| | Saracens v Wasps | TBC | 14:00 | 16:00 | Round 6 |
| |
| | Fri, 29 October 2021 |
| | Exeter Chiefs v Gloucester | Kingsholm Stadium | 18:45 | 20:45 | Round 7 |
| |
| | Sat, 30 October 2021 |
| | Sale Sharks v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 7 |
| | Leicester Tigers v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 7 |
| | Bristol v London Irish | Community Stadium | 14:00 | 16:00 | Round 7 |
| | Bath v Wasps | Recreation Ground | 14:00 | 16:00 | Round 7 |
| |
| | Sun, 31 October 2021 |
| | Harlequins v Saracens | Twickenham Stoop | 15:00 | 17:00 | Round 7 |
| |
| | Sat, 6 November 2021 |
| | Exeter Chiefs v Newcastle Falcons | Sandy Park Stadium | 15:00 | 17:00 | Round 8 |
| | Bath v Leicester Tigers | TBC | 15:00 | 17:00 | Round 8 |
| | Northampton Saints v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 8 |
| | London Irish v Saracens | TBC | 15:00 | 17:00 | Round 8 |
| | Harlequins v Wasps | TBC | 15:00 | 17:00 | Round 8 |
| | Bristol v Worcester Warriors | Ashton Gate | 15:00 | 17:00 | Round 8 |
| |
| | Sat, 27 November 2021 |
| | Bath v Exeter Chiefs | Recreation Ground | 15:00 | 17:00 | Round 9 |
| | Bristol v Northampton Saints | Ashton Gate | 15:00 | 17:00 | Round 9 |
| | Harlequins v London Irish | Twickenham Stoop | 15:00 | 17:00 | Round 9 |
| | Newcastle Falcons v Worcester Warriors | Kingston Park | 15:00 | 17:00 | Round 9 |
| | Sale Sharks v Saracens | TBC | 15:00 | 17:00 | Round 9 |
| | Gloucester v Wasps | TBC | 15:00 | 17:00 | Round 9 |
| |
| | Sat, 4 December 2021 |
| | Bath v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 10 |
| | London Irish v Newcastle Falcons | Community Stadium | 15:00 | 17:00 | Round 10 |
| | Wasps v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 10 |
| | Bristol v Gloucester | Kingsholm Stadium | 15:00 | 17:00 | Round 10 |
| | Harlequins v Leicester Tigers | TBC | 15:00 | 17:00 | Round 10 |
| | Exeter Chiefs v Saracens | Sandy Park Stadium | 15:00 | 17:00 | Round 10 |
| |
| | Sun, 26 December 2021 |
| | London Irish v Wasps | TBC | 15:00 | 17:00 | Round 11 |
| | Saracens v Worcester Warriors | TBC | 15:00 | 17:00 | Round 11 |
| | Newcastle Falcons v Sale Sharks | Kingston Park | 15:00 | 17:00 | Round 11 |
| | Bath v Gloucester | Recreation Ground | 15:00 | 17:00 | Round 11 |
| | Bristol v Leicester Tigers | Ashton Gate | 15:00 | 17:00 | Round 11 |
| | Harlequins v Northampton Saints | Twickenham Stoop | 15:00 | 17:00 | Round 11 |
| |
| | Sat, 1 January 2022 |
| | Bristol v Exeter Chiefs | Sandy Park Stadium | 15:00 | 17:00 | Round 12 |
| | Gloucester v Harlequins | Kingsholm Stadium | 15:00 | 17:00 | Round 12 |
| | Bath v London Irish | Community Stadium | 15:00 | 17:00 | Round 12 |
| | Northampton Saints v Saracens | Franklins Gardens | 15:00 | 17:00 | Round 12 |
| | Sale Sharks v Wasps | AJ Bell Stadium | 15:00 | 17:00 | Round 12 |
| | Leicester Tigers v Newcastle Falcons | TBC | 15:00 | 17:00 | Round 12 |
| |
| | Sat, 8 January 2022 |
| | Leicester Tigers v Wasps | TBC | 15:00 | 17:00 | Round 13 |
| | Bath v Worcester Warriors | Recreation Ground | 15:00 | 17:00 | Round 13 |
| | Bristol v Sale Sharks | Ashton Gate | 15:00 | 17:00 | Round 13 |
| | Exeter Chiefs v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 13 |
| | Newcastle Falcons v Northampton Saints | Kingston Park | 15:00 | 17:00 | Round 13 |
| | Gloucester v Saracens | TBC | 15:00 | 17:00 | Round 13 |
| |
| | Sat, 29 January 2022 |
| | Bath v Harlequins | Recreation Ground | 15:00 | 17:00 | Round 14 |
| | Gloucester v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 14 |
| | Leicester Tigers v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 14 |
| | Saracens v Wasps | TBC | 15:00 | 17:00 | Round 14 |
| | Northampton Saints v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 14 |
| | Exeter Chiefs v London Irish | Community Stadium | 15:00 | 17:00 | Round 14 |
| |
| | Sat, 5 February 2022 |
| | Leicester Tigers v Worcester Warriors | TBC | 15:00 | 17:00 | Round 15 |
| | Harlequins v Sale Sharks | Twickenham Stoop | 15:00 | 17:00 | Round 15 |
| | Bath v Saracens | TBC | 15:00 | 17:00 | Round 15 |
| | Exeter Chiefs v Wasps | Sandy Park Stadium | 15:00 | 17:00 | Round 15 |
| | Bristol v Newcastle Falcons | Ashton Gate | 15:00 | 17:00 | Round 15 |
| | Gloucester v London Irish | Kingsholm Stadium | 15:00 | 17:00 | Round 15 |
| |
| | Sat, 12 February 2022 |
| | Bristol v London Irish | Ashton Gate | 15:00 | 17:00 | Round 16 |
| | Exeter Chiefs v Gloucester | Sandy Park Stadium | 15:00 | 17:00 | Round 16 |
| | Leicester Tigers v Northampton Saints | TBC | 15:00 | 17:00 | Round 16 |
| | Sale Sharks v Worcester Warriors | AJ Bell Stadium | 15:00 | 17:00 | Round 16 |
| | Harlequins v Saracens | TBC | 15:00 | 17:00 | Round 16 |
| | Bath v Wasps | TBC | 15:00 | 17:00 | Round 16 |
| |
| | Sat, 19 February 2022 |
| | Bristol v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 17 |
| | Northampton Saints v Sale Sharks | Franklins Gardens | 15:00 | 17:00 | Round 17 |
| | Exeter Chiefs v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 17 |
| | London Irish v Saracens | Community Stadium | 15:00 | 17:00 | Round 17 |
| | Bath v Leicester Tigers | Recreation Ground | 15:00 | 17:00 | Round 17 |
| | Harlequins v Wasps | Twickenham Stoop | 15:00 | 17:00 | Round 17 |
| |
| | Sat, 26 February 2022 |
| | Bristol v Wasps | Ashton Gate | 15:00 | 17:00 | Round 18 |
| | Gloucester v Leicester Tigers | TBC | 15:00 | 17:00 | Round 18 |
| | Bath v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 18 |
| | Exeter Chiefs v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 18 |
| | London Irish v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 18 |
| | Harlequins v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 18 |
| |
| | Sat, 5 March 2022 |
| | Bath v Bristol | Recreation Ground | 15:00 | 17:00 | Round 19 |
| | Exeter Chiefs v Sale Sharks | Sandy Park Stadium | 15:00 | 17:00 | Round 19 |
| | Gloucester v Northampton Saints | Kingsholm Stadium | 15:00 | 17:00 | Round 19 |
| | Harlequins v Newcastle Falcons | Twickenham Stoop | 15:00 | 17:00 | Round 19 |
| | London Irish v Worcester Warriors | Community Stadium | 15:00 | 17:00 | Round 19 |
| | Leicester Tigers v Saracens | TBC | 15:00 | 17:00 | Round 19 |
| |
| | Sat, 12 March 2022 |
| | Exeter Chiefs v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 20 |
| | Northampton Saints v Wasps | Franklins Gardens | 15:00 | 17:00 | Round 20 |
| | Gloucester v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 20 |
| | Leicester Tigers v London Irish | TBC | 15:00 | 17:00 | Round 20 |
| | Bristol v Harlequins | Ashton Gate | 15:00 | 17:00 | Round 20 |
| | Newcastle Falcons v Saracens | Kingston Park | 15:00 | 17:00 | Round 20 |
| |
| | Sat, 26 March 2022 |
| | Bath v Sale Sharks | Recreation Ground | 15:00 | 17:00 | Round 21 |
| | Exeter Chiefs v Leicester Tigers | Sandy Park Stadium | 15:00 | 17:00 | Round 21 |
| | Gloucester v Wasps | Kingsholm Stadium | 15:00 | 17:00 | Round 21 |
| | London Irish v Northampton Saints | Community Stadium | 15:00 | 17:00 | Round 21 |
| | Bristol v Saracens | Tottenham Hotspur Stadium | 15:00 | 17:00 | Round 21 |
| | Newcastle Falcons v Wasps | TBC | 15:00 | 17:00 | Round 21 |
| |
| | Sat, 2 April 2022 |
| | Newcastle Falcons v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 22 |
| | Sale Sharks v Saracens | AJ Bell Stadium | 15:00 | 17:00 | Round 22 |
| | Bristol v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 22 |
| | Bath v Exeter Chiefs | Sandy Park Stadium | 15:00 | 17:00 | Round 22 |
| | Gloucester v Wasps | Kingsholm Stadium | 15:00 | 17:00 | Round 22 |
| | Harlequins v London Irish | Community Stadium | 15:00 | 17:00 | Round 22 |
| |
| | Sat, 23 April 2022 |
| | Exeter Chiefs v Saracens | TBC | 15:00 | 17:00 | Round 23 |
| | London Irish v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 23 |
| | Wasps v Worcester Warriors | TBC | 15:00 | 17:00 | Round 23 |
| | Bristol v Gloucester | Ashton Gate | 15:00 | 17:00 | Round 23 |
| | Bath v Northampton Saints | Recreation Ground | 15:00 | 17:00 | Round 23 |
| | Harlequins v Leicester Tigers | Twickenham Stoop | 15:00 | 17:00 | Round 23 |
| |
| | Sat, 30 April 2022 |
| | Bath v Gloucester | Kingsholm Stadium | 15:00 | 17:00 | Round 24 |
| | Bristol v Leicester Tigers | TBC | 15:00 | 17:00 | Round 24 |
| | London Irish v Wasps | Community Stadium | 15:00 | 17:00 | Round 24 |
| | Harlequins v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 24 |
| | Newcastle Falcons v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 24 |
| | Saracens v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 24 |
| |
| | Sat, 21 May 2022 |
| | Sale Sharks v Wasps | TBC | 15:00 | 17:00 | Round 25 |
| | Northampton Saints v Saracens | TBC | 15:00 | 17:00 | Round 25 |
| | Leicester Tigers v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 25 |
| | Gloucester v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 25 |
| | Bath v London Irish | Recreation Ground | 15:00 | 17:00 | Round 25 |
| | Bristol v Exeter Chiefs | Ashton Gate | 15:00 | 17:00 | Round 25 |
| |
| | Sat, 4 June 2022 |
| | Exeter Chiefs v Harlequins | Sandy Park Stadium | 15:00 | 17:00 | Round 26 |
| | Gloucester v Saracens | Kingsholm Stadium | 15:00 | 17:00 | Round 26 |
| | Leicester Tigers v Wasps | TBC | 15:00 | 17:00 | Round 26 |
| | Newcastle Falcons v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 26 |
| | Bristol v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 26 |
| | Bath v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 26 |
