| | FIXTURE | VENUE | GMT | LOCAL | POOL |
| | Fri, 17 September 2021 |
| | Saracens v Bristol | Ashton Gate | 0:00 | 2:00 | Round 1 |
| |
| | Sat, 18 September 2021 |
| | London Irish v Worcester Warriors | Sixways | 0:00 | 2:00 | Round 1 |
| | Bath v Sale Sharks | AJ Bell Stadium | 0:00 | 2:00 | Round 1 |
| | Exeter Chiefs v Leicester Tigers | Mattioli Woods Welford Road | 0:00 | 2:00 | Round 1 |
| | Gloucester v Northampton Saints | Franklins Gardens | 0:00 | 2:00 | Round 1 |
| |
| | Sun, 19 September 2021 |
| | Harlequins v Newcastle Falcons | Kings Park Stadium | 0:00 | 2:00 | Round 1 |
| |
| | Fri, 24 September 2021 |
| | Leicester Tigers v Gloucester | Kingsholm Stadium | 0:00 | 2:00 | Round 2 |
| |
| | Sat, 25 September 2021 |
| | Newcastle Falcons v Bath | Recreation Ground | 0:00 | 2:00 | Round 2 |
| | Northampton Saints v Exeter Chiefs | Sandy Park Stadium | 0:00 | 2:00 | Round 2 |
| | Worcester Warriors v Harlequins | Twickenham Stoop | 0:00 | 2:00 | Round 2 |
| | Bristol v Wasps | Coventry Building Society Arena | 0:00 | 2:00 | Round 2 |
| |
| | Sun, 26 September 2021 |
| | Sale Sharks v London Irish | Community Stadium | 0:00 | 2:00 | Round 2 |
| |
| | Fri, 1 October 2021 |
| | Saracens v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 3 |
| | Wasps v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 3 |
| | Bath v Bristol | Ashton Gate | 18:45 | 20:45 | Round 3 |
| |
| | Sat, 2 October 2021 |
| | London Irish v Northampton Saints | Franklins Gardens | 13:00 | 15:00 | Round 3 |
| | Gloucester v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 3 |
| |
| | Sun, 3 October 2021 |
| | Exeter Chiefs v Sale Sharks | AJ Bell Stadium | 14:00 | 16:00 | Round 3 |
| |
| | Fri, 8 October 2021 |
| | Bristol v Harlequins | Twickenham Stoop | 16:45 | 18:45 | Round 4 |
| |
| | Sat, 9 October 2021 |
| | Sale Sharks v Gloucester | Kingsholm Stadium | 10:00 | 12:00 | Round 4 |
| | Leicester Tigers v London Irish | Community Stadium | 10:00 | 12:00 | Round 4 |
| | Worcester Warriors v Exeter Chiefs | Sandy Park Stadium | 10:00 | 12:00 | Round 4 |
| | Newcastle Falcons v Saracens | StoneX Stadium | 12:00 | 14:00 | Round 4 |
| |
| | Sun, 10 October 2021 |
| | Northampton Saints v Wasps | Coventry Building Society Arena | 12:00 | 14:00 | Round 4 |
| |
| | Fri, 15 October 2021 |
| | Harlequins v Sale Sharks | AJ Bell Stadium | 18:45 | 20:45 | Round 5 |
| |
| | Sat, 16 October 2021 |
| | Exeter Chiefs v Wasps | Coventry Building Society Arena | 10:00 | 12:00 | Round 5 |
| | Leicester Tigers v Worcester Warriors | Sixways | 10:00 | 12:00 | Round 5 |
| | Bristol v Newcastle Falcons | Kingston Park | 12:00 | 14:00 | Round 5 |
| |
| | Sun, 17 October 2021 |
| | Gloucester v London Irish | Community Stadium | 10:00 | 12:00 | Round 5 |
| | Saracens v Bath | Recreation Ground | 12:00 | 14:00 | Round 5 |
| |
| | Fri, 22 October 2021 |
| | Worcester Warriors v Northampton Saints | Franklins Gardens | 14:45 | 16:45 | Round 6 |
| |
| | Sat, 23 October 2021 |
| | Newcastle Falcons v Gloucester | Kingsholm Stadium | 12:00 | 14:00 | Round 6 |
| | London Irish v Exeter Chiefs | Sandy Park Stadium | 12:00 | 14:00 | Round 6 |
| | Bath v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 6 |
| | Sale Sharks v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 6 |
| |
| | Sun, 24 October 2021 |
| | Wasps v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 6 |
| |
| | Fri, 29 October 2021 |
| | Exeter Chiefs v Gloucester | Kingsholm Stadium | 18:45 | 20:45 | Round 7 |
| |
| | Sat, 30 October 2021 |
| | Sale Sharks v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 7 |
| | Leicester Tigers v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 7 |
| | Bristol v London Irish | Community Stadium | 14:00 | 16:00 | Round 7 |
| | Wasps v Bath | Recreation Ground | 14:00 | 16:00 | Round 7 |
| |
| | Sun, 31 October 2021 |
| | Saracens v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 7 |
| |
| | Fri, 5 November 2021 |
| | Bath v Leicester Tigers | Mattioli Woods Welford Road | 19:45 | 21:45 | Round 8 |
| |
| | Sat, 6 November 2021 |
| | London Irish v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 8 |
| | Worcester Warriors v Bristol | Ashton Gate | 15:00 | 17:00 | Round 8 |
| | Northampton Saints v Sale Sharks | AJ Bell Stadium | 17:00 | 19:00 | Round 8 |
| | Newcastle Falcons v Exeter Chiefs | Sandy Park Stadium | 17:30 | 19:30 | Round 8 |
| |
| | Sun, 7 November 2021 |
| | Harlequins v Wasps | Coventry Building Society Arena | 16:30 | 18:30 | Round 8 |
| |
| | Fri, 26 November 2021 |
| | Exeter Chiefs v Bath | Recreation Ground | 19:45 | 21:45 | Round 9 |
| | Northampton Saints v Bristol | Ashton Gate | 19:45 | 21:45 | Round 9 |
| | Gloucester v Wasps | Coventry Building Society Arena | 19:45 | 21:45 | Round 9 |
| |
| | Sat, 27 November 2021 |
| | London Irish v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 9 |
| | Worcester Warriors v Newcastle Falcons | Kingston Park | 18:00 | 20:00 | Round 9 |
| |
| | Sun, 28 November 2021 |
| | Sale Sharks v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 9 |
| |
| | Fri, 3 December 2021 |
| | Bristol v Gloucester | Kingsholm Stadium | 19:45 | 21:45 | Round 10 |
| |
| | Sat, 4 December 2021 |
| | Bath v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 10 |
| | Newcastle Falcons v London Irish | Community Stadium | 15:00 | 17:00 | Round 10 |
| | Wasps v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 10 |
| | Saracens v Exeter Chiefs | Sandy Park Stadium | 15:00 | 17:00 | Round 10 |
| |
| | Sun, 5 December 2021 |
| | Harlequins v Leicester Tigers | Mattioli Woods Welford Road | 15:00 | 17:00 | Round 10 |
| |
| | Sun, 26 December 2021 |
| | Leicester Tigers v Bristol | Ashton Gate | 14:00 | 16:00 | Round 11 |
| | Sale Sharks v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 11 |
| | Worcester Warriors v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 11 |
| | London Irish v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 11 |
| | Gloucester v Bath | Recreation Ground | 16:30 | 18:30 | Round 11 |
| |
| | Mon, 27 December 2021 |
| | Northampton Saints v Harlequins | Twickenham | 17:00 | 19:00 | Round 11 |
| |
| | Sat, 1 January 2022 |
| | Wasps v Sale Sharks | AJ Bell Stadium | 14:00 | 16:00 | Round 12 |
| | Bristol v Exeter Chiefs | Sandy Park Stadium | 16:30 | 18:30 | Round 12 |
| |
| | Sun, 2 January 2022 |
| | Saracens v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 12 |
| | Newcastle Falcons v Leicester Tigers | Mattioli Woods Welford Road | 15:00 | 17:00 | Round 12 |
| | Harlequins v Gloucester | Kingsholm Stadium | 15:00 | 17:00 | Round 12 |
| |
| | Mon, 3 January 2022 |
| | Bath v London Irish | Community Stadium | 15:00 | 17:00 | Round 12 |
| |
| | Fri, 7 January 2022 |
| | Sale Sharks v Bristol | Ashton Gate | 19:45 | 21:45 | Round 13 |
| |
| | Sat, 8 January 2022 |
| | Exeter Chiefs v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 13 |
| | Northampton Saints v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 13 |
| | Gloucester v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 13 |
| |
| | Sun, 9 January 2022 |
| | Leicester Tigers v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 13 |
| | Worcester Warriors v Bath | Recreation Ground | 15:00 | 17:00 | Round 13 |
| |
| | Fri, 28 January 2022 |
| | Harlequins v Bath | Recreation Ground | 19:45 | 21:45 | Round 14 |
| |
| | Sat, 29 January 2022 |
| | Gloucester v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 14 |
| | Northampton Saints v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 14 |
| | Exeter Chiefs v London Irish | Community Stadium | 15:00 | 17:00 | Round 14 |
| |
| | Sun, 30 January 2022 |
| | Leicester Tigers v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 14 |
| | Saracens v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 14 |
| |
| | Fri, 4 February 2022 |
| | London Irish v Gloucester | Kingsholm Stadium | 19:45 | 21:45 | Round 15 |
| |
| | Sat, 5 February 2022 |
| | Newcastle Falcons v Bristol | Ashton Gate | 14:00 | 16:00 | Round 15 |
| | Wasps v Exeter Chiefs | Sandy Park Stadium | 14:30 | 16:30 | Round 15 |
| | Worcester Warriors v Leicester Tigers | Mattioli Woods Welford Road | 15:00 | 17:00 | Round 15 |
| | Bath v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 15 |
| |
| | Sun, 6 February 2022 |
| | Sale Sharks v Harlequins | Twickenham Stoop | 13:00 | 15:00 | Round 15 |
| |
| | Fri, 11 February 2022 |
| | Northampton Saints v Leicester Tigers | Mattioli Woods Welford Road | 19:45 | 21:45 | Round 16 |
| | London Irish v Bristol | Ashton Gate | 19:46 | 21:46 | Round 16 |
| |
| | Sat, 12 February 2022 |
| | Gloucester v Exeter Chiefs | Sandy Park Stadium | 15:00 | 17:00 | Round 16 |
| | Worcester Warriors v Sale Sharks | AJ Bell Stadium | 15:00 | 17:00 | Round 16 |
| | Bath v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 16 |
| |
| | Sun, 13 February 2022 |
| | Harlequins v Saracens | StoneX Stadium | 13:00 | 15:00 | Round 16 |
| |
| | Fri, 18 February 2022 |
| | Bristol v Worcester Warriors | Sixways | 19:45 | 21:45 | Round 17 |
| |
| | Sat, 19 February 2022 |
| | Sale Sharks v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 17 |
| | Saracens v London Irish | Community Stadium | 15:00 | 17:00 | Round 17 |
| | Wasps v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 17 |
| | Leicester Tigers v Bath | Recreation Ground | 15:00 | 17:00 | Round 17 |
| |
| | Sun, 20 February 2022 |
| | Exeter Chiefs v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 17 |
| |
| | Sat, 26 February 2022 |
| | Wasps v Bristol | Ashton Gate | 13:00 | 15:00 | Round 18 |
| | Gloucester v Leicester Tigers | Mattioli Woods Welford Road | 13:00 | 15:00 | Round 18 |
| | Bath v Newcastle Falcons | Kingston Park | 13:00 | 15:00 | Round 18 |
| | Exeter Chiefs v Northampton Saints | Franklins Gardens | 13:00 | 15:00 | Round 18 |
| | London Irish v Sale Sharks | AJ Bell Stadium | 13:00 | 15:00 | Round 18 |
| | Harlequins v Worcester Warriors | Sixways | 13:00 | 15:00 | Round 18 |
| |
| | Sat, 5 March 2022 |
| | Leicester Tigers v Saracens | StoneX Stadium | 13:00 | 15:00 | Round 19 |
| | Worcester Warriors v London Irish | Community Stadium | 13:00 | 15:00 | Round 19 |
| | Newcastle Falcons v Harlequins | Twickenham Stoop | 13:00 | 15:00 | Round 19 |
| | Bristol v Bath | Recreation Ground | 13:00 | 15:00 | Round 19 |
| | Sale Sharks v Exeter Chiefs | Sandy Park Stadium | 13:00 | 15:00 | Round 19 |
| | Northampton Saints v Gloucester | Kingsholm Stadium | 13:00 | 15:00 | Round 19 |
| |
| | Sat, 12 March 2022 |
| | Exeter Chiefs v Worcester Warriors | Sixways | 13:00 | 15:00 | Round 20 |
| | Wasps v Northampton Saints | Welford Road | 13:00 | 15:00 | Round 20 |
| | Gloucester v Sale Sharks | AJ Bell Stadium | 13:00 | 15:00 | Round 20 |
| | London Irish v Leicester Tigers | Mattioli Woods Welford Road | 13:00 | 15:00 | Round 20 |
| | Harlequins v Bristol | Ashton Gate | 13:00 | 15:00 | Round 20 |
| | Saracens v Newcastle Falcons | Kingston Park | 13:00 | 15:00 | Round 20 |
| |
| | Sat, 26 March 2022 |
| | Sale Sharks v Bath | Recreation Ground | 13:00 | 15:00 | Round 21 |
| | Leicester Tigers v Exeter Chiefs | Sandy Park Stadium | 13:00 | 15:00 | Round 21 |
| | Wasps v Gloucester | Kingsholm Stadium | 13:00 | 15:00 | Round 21 |
| | Northampton Saints v London Irish | Community Stadium | 13:00 | 15:00 | Round 21 |
| | Bristol v Saracens | Tottenham Hotspur Stadium | 13:00 | 15:00 | Round 21 |
| | Newcastle Falcons v Wasps | Coventry Building Society Arena | 13:00 | 15:00 | Round 21 |
| |
| | Sat, 2 April 2022 |
| | Newcastle Falcons v Worcester Warriors | Sixways | 13:00 | 15:00 | Round 22 |
| | Saracens v Sale Sharks | AJ Bell Stadium | 13:00 | 15:00 | Round 22 |
| | Bristol v Northampton Saints | Franklins Gardens | 13:00 | 15:00 | Round 22 |
| | Bath v Exeter Chiefs | Sandy Park Stadium | 13:00 | 15:00 | Round 22 |
| | Wasps v Gloucester | Kingsholm Stadium | 13:00 | 15:00 | Round 22 |
| | Harlequins v London Irish | Community Stadium | 13:00 | 15:00 | Round 22 |
| |
| | Sat, 23 April 2022 |
| | Exeter Chiefs v Saracens | StoneX Stadium | 13:00 | 15:00 | Round 23 |
| | London Irish v Newcastle Falcons | Kingston Park | 13:00 | 15:00 | Round 23 |
| | Worcester Warriors v Wasps | Coventry Building Society Arena | 13:00 | 15:00 | Round 23 |
| | Gloucester v Bristol | Ashton Gate | 13:00 | 15:00 | Round 23 |
| | Northampton Saints v Bath | Recreation Ground | 13:00 | 15:00 | Round 23 |
| | Leicester Tigers v Harlequins | Twickenham Stoop | 13:00 | 15:00 | Round 23 |
| |
| | Sat, 30 April 2022 |
| | Bath v Gloucester | Kingsholm Stadium | 13:00 | 15:00 | Round 24 |
| | Bristol v Leicester Tigers | Mattioli Woods Welford Road | 13:00 | 15:00 | Round 24 |
| | Wasps v London Irish | Community Stadium | 13:00 | 15:00 | Round 24 |
| | Harlequins v Northampton Saints | Franklins Gardens | 13:00 | 15:00 | Round 24 |
| | Newcastle Falcons v Sale Sharks | AJ Bell Stadium | 13:00 | 15:00 | Round 24 |
| | Saracens v Worcester Warriors | Sixways | 13:00 | 15:00 | Round 24 |
| |
| | Sat, 21 May 2022 |
| | Sale Sharks v Wasps | Coventry Building Society Arena | 13:00 | 15:00 | Round 25 |
| | Northampton Saints v Saracens | StoneX Stadium | 13:00 | 15:00 | Round 25 |
| | Leicester Tigers v Newcastle Falcons | Kingston Park | 13:00 | 15:00 | Round 25 |
| | Gloucester v Harlequins | Twickenham Stoop | 13:00 | 15:00 | Round 25 |
| | London Irish v Bath | Recreation Ground | 13:00 | 15:00 | Round 25 |
| | Exeter Chiefs v Bristol | Ashton Gate | 13:00 | 15:00 | Round 25 |
| |
| | Sat, 4 June 2022 |
| | Harlequins v Exeter Chiefs | Sandy Park Stadium | 13:00 | 15:00 | Round 26 |
| | Saracens v Gloucester | Kingsholm Stadium | 13:00 | 15:00 | Round 26 |
| | Wasps v Leicester Tigers | Mattioli Woods Welford Road | 13:00 | 15:00 | Round 26 |
| | Newcastle Falcons v Northampton Saints | Franklins Gardens | 13:00 | 15:00 | Round 26 |
| | Bristol v Sale Sharks | AJ Bell Stadium | 13:00 | 15:00 | Round 26 |
| | Bath v Worcester Warriors | Sixways | 13:00 | 15:00 | Round 26 |
