| | FIXTURE | VENUE | GMT | LOCAL | POOL |
| | Fri, 9 September 2022 |
| | Bath v Bristol | Ashton Gate | 18:45 | 20:45 | Round 1 |
| | Northampton Saints v Sale Sharks | Salford City Stadium | 18:45 | 20:45 | Round 1 |
| |
| | Sat, 10 September 2022 |
| | Worcester Warriors v London Irish | Community Stadium | 14:00 | 16:00 | Round 1 |
| | Harlequins v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 1 |
| | Leicester Tigers v Exeter Chiefs | Sandy Park Stadium | 18:45 | 20:45 | Round 1 |
| |
| | Sun, 11 September 2022 |
| | Wasps v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 1 |
| |
| | Fri, 16 September 2022 |
| | London Irish v Northampton Saints | Franklins Gardens | 18:45 | 20:45 | Round 2 |
| |
| | Sat, 17 September 2022 |
| | Sale Sharks v Bath | Recreation Ground | 14:00 | 16:00 | Round 2 |
| | Saracens v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 2 |
| | Newcastle Falcons v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 2 |
| | Bristol v Wasps | Coventry Building Society Arena | 14:00 | 16:00 | Round 2 |
| |
| | Sun, 18 September 2022 |
| | Exeter Chiefs v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 2 |
| |
| | Fri, 23 September 2022 |
| | Wasps v Bath | Recreation Ground | 18:45 | 20:45 | Round 3 |
| |
| | Sat, 24 September 2022 |
| | Newcastle Falcons v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 3 |
| | Gloucester v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 3 |
| | London Irish v Bristol | Ashton Gate | 14:00 | 16:00 | Round 3 |
| | Leicester Tigers v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 3 |
| |
| | Sun, 25 September 2022 |
| | Harlequins v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 3 |
| |
| | Fri, 30 September 2022 |
| | Bristol v Newcastle Falcons | Kingston Park | 18:45 | 20:45 | Round 4 |
| |
| | Sat, 1 October 2022 |
| | Worcester Warriors v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 4 |
| | Bath v London Irish | Community Stadium | 14:00 | 16:00 | Round 4 |
| | Exeter Chiefs v Sale Sharks | Salford City Stadium | 14:00 | 16:00 | Round 4 |
| | Leicester Tigers v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 4 |
| |
| | Sun, 2 October 2022 |
| | Northampton Saints v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 4 |
| |
| | Fri, 7 October 2022 |
| | Exeter Chiefs v Bristol | Ashton Gate | 18:45 | 20:45 | Round 5 |
| |
| | Sat, 8 October 2022 |
| | Saracens v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 5 |
| | Harlequins v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 5 |
| | Sale Sharks v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 5 |
| | Gloucester v Bath | Recreation Ground | 14:00 | 16:00 | Round 5 |
| |
| | Sun, 9 October 2022 |
| | Northampton Saints v Wasps | Coventry Building Society Arena | 14:00 | 16:00 | Round 5 |
| |
| | Sat, 15 October 2022 |
| | Wasps v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 6 |
| | Bristol v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 6 |
| | Newcastle Falcons v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 6 |
| | Bath v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 6 |
| | London Irish v Sale Sharks | Salford City Stadium | 18:45 | 20:45 | Round 6 |
| |
| | Sun, 16 October 2022 |
| | Leicester Tigers v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 6 |
| |
| | Fri, 21 October 2022 |
| | Gloucester v London Irish | Community Stadium | 18:45 | 20:45 | Round 7 |
| |
| | Sat, 22 October 2022 |
| | Worcester Warriors v Bristol | Ashton Gate | 14:00 | 16:00 | Round 7 |
| | Wasps v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 7 |
| | Northampton Saints v Bath | Recreation Ground | 14:00 | 16:00 | Round 7 |
| | Saracens v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 7 |
| |
| | Sun, 23 October 2022 |
| | Harlequins v Sale Sharks | Salford City Stadium | 14:00 | 16:00 | Round 7 |
| |
| | Fri, 28 October 2022 |
| | Exeter Chiefs v Gloucester | Kingsholm Stadium | 18:45 | 20:45 | Round 8 |
| |
| | Sat, 29 October 2022 |
| | London Irish v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 8 |
| | Bristol v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 8 |
| | Bath v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 8 |
| |
| | Sun, 30 October 2022 |
| | Sale Sharks v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 8 |
| | Newcastle Falcons v Wasps | Coventry Building Society Arena | 14:00 | 16:00 | Round 8 |
| |
| | Fri, 4 November 2022 |
| | Exeter Chiefs v Northampton Saints | Franklins Gardens | 19:45 | 21:45 | Round 9 |
| |
| | Sat, 5 November 2022 |
| | Gloucester v Sale Sharks | Salford City Stadium | 13:00 | 15:00 | Round 9 |
| | Worcester Warriors v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 9 |
| | Wasps v London Irish | Community Stadium | 14:00 | 16:00 | Round 9 |
| | Bath v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 9 |
| | Saracens v Bristol | Ashton Gate | 17:00 | 19:00 | Round 9 |
| |
| | Fri, 11 November 2022 |
| | Leicester Tigers v Bath | Recreation Ground | 19:45 | 21:45 | Round 10 |
| |
| | Sat, 12 November 2022 |
| | Newcastle Falcons v Gloucester | Kingsholm Stadium | 15:00 | 17:00 | Round 10 |
| | Sale Sharks v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 10 |
| | London Irish v Exeter Chiefs | Sandy Park Stadium | 17:00 | 19:00 | Round 10 |
| |
| | Sun, 13 November 2022 |
| | Harlequins v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 10 |
| | Northampton Saints v Saracens | Kingston Park | 15:00 | 17:00 | Round 10 |
| |
| | Sat, 26 November 2022 |
| | Exeter Chiefs v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 11 |
| | Wasps v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 11 |
| | Worcester Warriors v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 11 |
| | London Irish v Leicester Tigers | Mattioli Woods Welford Road | 15:00 | 17:00 | Round 11 |
| | Bristol v Sale Sharks | Salford City Stadium | 15:00 | 17:00 | Round 11 |
| | Gloucester v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 11 |
| |
| | Sat, 3 December 2022 |
| | Sale Sharks v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 12 |
| | Newcastle Falcons v London Irish | Community Stadium | 15:00 | 17:00 | Round 12 |
| | Northampton Saints v Gloucester | Kingsholm Stadium | 15:00 | 17:00 | Round 12 |
| | Leicester Tigers v Bristol | Ashton Gate | 15:00 | 17:00 | Round 12 |
| | Harlequins v Bath | Recreation Ground | 15:00 | 17:00 | Round 12 |
| | Saracens v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 12 |
| |
| | Sat, 24 December 2022 |
| | Saracens v London Irish | Community Stadium | 15:00 | 17:00 | Round 13 |
| | Worcester Warriors v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 13 |
| | Sale Sharks v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 13 |
| | Bristol v Harlequins | Twickenham | 15:00 | 17:00 | Round 13 |
| | Gloucester v Leicester Tigers | Mattioli Woods Welford Road | 15:00 | 17:00 | Round 13 |
| |
| | Sun, 25 December 2022 |
| | Bath v Exeter Chiefs | Sandy Park Stadium | 15:00 | 17:00 | Round 13 |
| |
| | Sat, 31 December 2022 |
| | London Irish v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 14 |
| | Newcastle Falcons v Bath | Recreation Ground | 15:00 | 17:00 | Round 14 |
| | Exeter Chiefs v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 14 |
| | Wasps v Bristol | Ashton Gate | 15:00 | 17:00 | Round 14 |
| | Leicester Tigers v Sale Sharks | Salford City Stadium | 15:00 | 17:00 | Round 14 |
| | Harlequins v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 14 |
| |
| | Sat, 7 January 2023 |
| | Worcester Warriors v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 15 |
| | Bristol v London Irish | Community Stadium | 14:00 | 16:00 | Round 15 |
| | Northampton Saints v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 15 |
| | Bath v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 15 |
| | Wasps v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 15 |
| | Newcastle Falcons v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 15 |
| |
| | Sat, 28 January 2023 |
| | Gloucester v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 16 |
| | Saracens v Bath | Recreation Ground | 14:00 | 16:00 | Round 16 |
| | Northampton Saints v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 16 |
| | Sale Sharks v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 16 |
| | London Irish v Wasps | Coventry Building Society Arena | 14:23 | 16:23 | Round 16 |
| | Leicester Tigers v Worcester Warriors | Sixways | 14:24 | 16:24 | Round 16 |
| |
| | Sat, 4 February 2023 |
| | Newcastle Falcons v Bristol | Ashton Gate | 14:04 | 16:04 | Round 17 |
| | London Irish v Gloucester | Kingsholm Stadium | 14:26 | 16:26 | Round 17 |
| | Harlequins v Leicester Tigers | Mattioli Woods Welford Road | 14:27 | 16:27 | Round 17 |
| | Bath v Northampton Saints | Franklins Gardens | 14:28 | 16:28 | Round 17 |
| | Worcester Warriors v Sale Sharks | Salford City Stadium | 14:29 | 16:29 | Round 17 |
| | Exeter Chiefs v Wasps | Coventry Building Society Arena | 14:30 | 16:30 | Round 17 |
| |
| | Sat, 11 February 2023 |
| | Exeter Chiefs v Bath | Recreation Ground | 14:31 | 16:31 | Round 18 |
| | Sale Sharks v London Irish | Community Stadium | 14:32 | 16:32 | Round 18 |
| | Leicester Tigers v Newcastle Falcons | Kingston Park | 14:33 | 16:33 | Round 18 |
| | Gloucester v Northampton Saints | Franklins Gardens | 14:34 | 16:34 | Round 18 |
| | Bristol v Saracens | StoneX Stadium | 14:34 | 16:34 | Round 18 |
| | Wasps v Worcester Warriors | Sixways | 14:36 | 16:36 | Round 18 |
| |
| | Sat, 18 February 2023 |
| | Sale Sharks v Exeter Chiefs | Sandy Park Stadium | 14:37 | 16:37 | Round 19 |
| | Saracens v Gloucester | Kingsholm Stadium | 14:38 | 16:38 | Round 19 |
| | Newcastle Falcons v Harlequins | Twickenham Stoop | 14:38 | 16:38 | Round 19 |
| | Bristol v Leicester Tigers | Mattioli Woods Welford Road | 14:39 | 16:39 | Round 19 |
| | Bath v Wasps | Coventry Building Society Arena | 14:40 | 16:40 | Round 19 |
| | Northampton Saints v Worcester Warriors | Sixways | 14:41 | 16:41 | Round 19 |
| |
| | Sat, 4 March 2023 |
| | London Irish v Bath | Recreation Ground | 14:42 | 16:42 | Round 20 |
| | Northampton Saints v Bristol | Ashton Gate | 14:43 | 16:43 | Round 20 |
| | Worcester Warriors v Harlequins | Twickenham Stoop | 14:44 | 16:44 | Round 20 |
| | Exeter Chiefs v Leicester Tigers | Mattioli Woods Welford Road | 14:44 | 16:44 | Round 20 |
| | Gloucester v Newcastle Falcons | Kingston Park | 14:45 | 16:45 | Round 20 |
| | Saracens v Sale Sharks | Salford City Stadium | 14:46 | 16:46 | Round 20 |
| |
| | Sat, 11 March 2023 |
| | Bristol v Exeter Chiefs | Sandy Park Stadium | 14:47 | 16:47 | Round 21 |
| | Harlequins v Gloucester | Kingsholm Stadium | 14:48 | 16:48 | Round 21 |
| | Leicester Tigers v London Irish | Community Stadium | 14:48 | 16:48 | Round 21 |
| | Wasps v Northampton Saints | Franklins Gardens | 14:49 | 16:49 | Round 21 |
| | Bath v Sale Sharks | Salford City Stadium | 14:49 | 16:49 | Round 21 |
| | Worcester Warriors v Saracens | StoneX Stadium | 14:50 | 16:50 | Round 21 |
| |
| | Sat, 18 March 2023 |
| | Bath v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 22 |
| | London Irish v Newcastle Falcons | Kingston Park | 14:28 | 16:28 | Round 22 |
| | Gloucester v Worcester Warriors | Sixways | 14:44 | 16:44 | Round 22 |
| | Saracens v Wasps | Coventry Building Society Arena | 14:45 | 16:45 | Round 22 |
| | Sale Sharks v Bristol | Ashton Gate | 14:51 | 16:51 | Round 22 |
| | Exeter Chiefs v Harlequins | Twickenham Stoop | 14:52 | 16:52 | Round 22 |
| |
| | Sat, 25 March 2023 |
| | Bristol v Bath | Recreation Ground | 14:56 | 16:56 | Round 23 |
| | Newcastle Falcons v Exeter Chiefs | Sandy Park Stadium | 14:57 | 16:57 | Round 23 |
| | Leicester Tigers v Gloucester | Kingsholm Stadium | 14:57 | 16:57 | Round 23 |
| | Northampton Saints v London Irish | Community Stadium | 14:58 | 16:58 | Round 23 |
| | Wasps v Sale Sharks | Salford City Stadium | 14:58 | 16:58 | Round 23 |
| | Harlequins v Saracens | Tottenham Hotspur Stadium | 14:59 | 16:59 | Round 23 |
| |
| | Sat, 15 April 2023 |
| | Saracens v Leicester Tigers | Mattioli Woods Welford Road | 14:01 | 16:01 | Round 24 |
| | Exeter Chiefs v London Irish | Community Stadium | 14:02 | 16:02 | Round 24 |
| | Worcester Warriors v Newcastle Falcons | Kingston Park | 14:02 | 16:02 | Round 24 |
| | Sale Sharks v Northampton Saints | Franklins Gardens | 14:03 | 16:03 | Round 24 |
| | Gloucester v Wasps | Coventry Building Society Arena | 14:04 | 16:04 | Round 24 |
| | Harlequins v Bristol | Ashton Gate | 14:07 | 16:07 | Round 24 |
| |
| | Sat, 22 April 2023 |
| | Northampton Saints v Exeter Chiefs | Sandy Park Stadium | 14:05 | 16:05 | Round 25 |
| | Sale Sharks v Gloucester | Kingsholm Stadium | 14:06 | 16:06 | Round 25 |
| | Bath v Harlequins | Twickenham | 14:07 | 16:07 | Round 25 |
| | Wasps v Newcastle Falcons | Kingston Park | 14:08 | 16:08 | Round 25 |
| | London Irish v Saracens | StoneX Stadium | 14:09 | 16:09 | Round 25 |
| | Bristol v Worcester Warriors | Sixways | 14:10 | 16:10 | Round 25 |
| |
| | Sat, 6 May 2023 |
| | Worcester Warriors v Bath | Recreation Ground | 14:12 | 16:12 | Round 26 |
| | Gloucester v Bristol | Ashton Gate | 14:12 | 16:12 | Round 26 |
| | Harlequins v London Irish | Community Stadium | 14:13 | 16:13 | Round 26 |
| | Saracens v Northampton Saints | Franklins Gardens | 14:15 | 16:15 | Round 26 |
| | Newcastle Falcons v Sale Sharks | Salford City Stadium | 14:15 | 16:15 | Round 26 |
| | Leicester Tigers v Wasps | Coventry Building Society Arena | 14:16 | 16:16 | Round 26 |
