Hughes back for Calcutta Cup showdown
Hughes could come back into the side at No.8 at Murrayfield in the absence of Sam Simmonds, who will miss the next two rounds with a shoulder injury.
Wasps forward Hughes has been sidelined for six weeks, but came through a demanding training camp last week.
Head coach Eddie Jones has also named prop Joe Marler and back-row forward James Haskell in a 29-man group for the Calcutta Cup showdown after the duo served suspensions.
England recorded victories in their first two matches against Italy and Wales as they attempt to become the first team to win the tournament outright three years in a row.
Forwards: Dan Cole, Charlie Ewels, Jamie George, Dylan Hartley (captain), James Haskell, Nathan Hughes, Maro Itoje, George Kruis, Courtney Lawes, Joe Launchbury, Joe Marler, Chris Robshaw, Sam Underhill, Mako Vunipola, Harry Williams.
Backs: Mike Brown, Danny Care, Nathan Earle, Owen Farrell, George Ford, Gabriel Ibitoye (apprentice), Jonathan Joseph, Harry Mallinder, Jonny May, Jack Nowell, Denny Solomona, Ben Te’o, Anthony Watson, Richard Wigglesworth.