Bok scrumhalf back for Sharks
Schreuder returns from injury to replace Cameron Wright who took a knock in the Lions' game. Wright will play off the bench.
The other two changes (one a positional switch) in the backline see Sibusiso Nkosi shifting to the left wing in place of Makazole Mapimpi (who is being rested), with Jacobus van Wyk named on the right wing after playing off the bench two weeks ago.
Meanwhile, Tendai Mtawarira is back in the starting line-up after playing off the bench against the Lions.
Keegan Daniel also returns to the starting XV after he was a late withdrawal from the Lions game due to being unwell.
Tyler Paul comes in for Philip van der Walt, who has an ankle ligament sprain.
Sharks: 15 Lwazi Mvovo, 14 Jacobus van Wyk, 13 Lukhanyo Am, 12 Andre Esterhuizen, 11 Sibusiso Nkosi, 10 Robert du Preez, 9 Louis Schreuder, 8 Keegan Daniel, 7 Tyler Paul, 6 Jacques Vermeulen, 5 Stephan Lewies, 4 Ruan Botha (captain), 3 Thomas du Toit, 2 Franco Marais, 1 Tendai Mtawarira.
Replacements: 16 Armand van der Merwe, 17 Juan Schoeman, 18 John-Hubert Meyer, 19 Hyron Andrews, 20 Lubabalo Mtembu, 21 Cameron Wright, 22 Marius Louw, 23 Curwin Bosch.
Date: Saturday, March 3
Venue: Kings Park, Durban
Kick-off: 15.05 (13.05 GMT; 00.05 AEST, Sunday, March 3)
Referee: Jaco Peyper (South Africa)
Assistant referees: AJ Jacobs (South Africa), Archie Sehlako (South Africa)
TMO: Marius Jonker (South Africa)