Bosch trusted with No.10 jersey against Lions
The one change sees Curwin Bosch being recalled to start at flyhalf with Garth April taking his place on the bench.
Amongst the reserves, Franco Marais who has been on the sidelines with concussion is bracketed on the bench with Stephan Coetzee, pending a late call.
Philip van der Walt will lead the side at Ellis Park.
It will be the third time these two teams meet in Super Rugby this year.
In the first clash this year in Johannesburg, the Lions edged the Sharks 34-29.
In the reverse fixture last week in Durban, the Lions won 27-10.
Sharks: 15 Lwazi Mvovo, 14 Jacobus van Wyk, 13 Lukhanyo Am, 12 Andre Esterhuizen, 11 Sibusiso Nkosi, 10 Curwin Bosch, 9 Jacobus Reinach, 8 Daniel du Preez, 7 Jean-Luc du Preez, 6 Philip van der Walt (captain), 5 Stephan Lewies, 4 Etienne Oosthuizen, 3 Coenraad Oosthuizen, 2 Mahlatse Ralepelle, 1 Thomas du Toit.
Replacements: 16 Franco Marais/Stephan Coetzee, 17 Juan Schoeman, 18 Lourens Adriaanse, 19 Jean Droste, 20 Lubabalo Mtembu, 21 Michael Claassens, 22 Garth April.
Date: Saturday, July 22
Venue: Ellis Park, Johannesburg
Kick-off: 14.30 (12.30 GMT)
Referee: Marius van der Westhuizen (South Africa)
Assistant referees: Jaco van Heerden (South Africa), Egon Seconds (South Africa)
TMO: Marius Jonker (South Africa)