Spotlight on Haylett-Petty brothers against Jaguares
Flank Richard Hardwick, prop Sam Talakai, lock Geoff Parling, join Ross and Dane Haylett-Petty as the returns to the starting XV, while Jermaine Ainsley, Matt Philip and Lopeti Timani have been included on the bench.
Centre Reece Hodge will miss his first match since Round Four in the 2016 Super Rugby season with a hamstring strain, while loose forward Angus Cottrell has been omitted.
Both Hardwick and Talakai will start on the field for the first time in their Rebels career, while Anaru Rangi's form has kept Wallabies hooker Jordan Uelese on the bench.
Dane Haylett-Petty will return to fullback after overcoming a concussion sustained in Round Five, leaving Jack Maddocks to return to the wing. Tom English will partner Billy Meakes in the centres.
Former England international and British and Irish Lion, Geoff Parling will partner captain Adam Coleman in the second row.
Melbourne Rebels: 15 Dane Haylett-Petty, 14 Jack Maddocks, 13 Tom English, 12 Billy Meakes, 11 Marika Koroibete, 10 Jack Debreczeni, 9 Will Genia, 8 Amanaki Mafi, 7 Richard Hardwick, 6 Ross Haylett-Petty, 5 Adam Coleman, 4 Geoff Parling, 3 Sam Talakai, 2 Anaru Rangi, 1 Tetera Faulkner.
Replacements: 16 Jordan Uelese, 17 Ben Daley, 18 Jermaine Ainsley, 19 Matt Philip, 20 Colby Fainga'a, 21 Lopeti Timani, 22 Michael Ruru, 23 Sefa Naivalu.
Date: Saturday, April 14
Venue: AAMI Park, Melbourne
Kick-off: 15.15 (02.15; Argentina time; 05.15 GMT)
Referee: Nicholas Berry (Australia)
Assistant referees: William Houston (Australia), Graham Cooper (Australia)
TMO: Damien Mitchelmore (Australia)