Ford gets the axe
Dylan Hartley will lead England into battle against Australia in Brisbane on Saturday, with a side that has a total of 539 international caps.
Saracens' Owen Farrell starts at flyhalf ahead of Ford, with Northampton Saints' Luther Burrell alongside Farrell at inside centre.
Harlequins' Marland Yarde retains his place on the wing after a strong performance against Wales at Twickenham last month.
The pack is unchanged from the one that started in Paris earlier in the year, when England beat France to be crowned Six Nations champions.
Fullback Mike Brown will win his 50th England cap when he runs out at Suncorp Stadium on Saturday.
"We have picked a side to win in Brisbane," said England coach Eddie Jones.
"As always selection was tight and naturally players are disappointed, but we've gone with a 23 that has a good mix of experience and youth.
"We aim to win every Test match we play and I am pleased with our preparation since we landed in Australia.
"The group have acclimatised well, trained hard and there's a buzz around the camp."
England have never won a Test series in Australia and Jones urged his side to get the Southern Hemisphere tour off to a winning start and "create history".
"If you look at England's record in Australia it's pretty ordinary," he said.
"We've only ever won three games in Australia so it's a great opportunity to put down a marker and create history. It's important we get off to a positive start and we'll arrive in Brisbane ready to play physical and aggressive rugby.
"We're excited to be playing against a strong Australian team in their backyard. The Wallabies are ranked second in the world and have the World Rugby coach of the year, so that's why they start as favourites. There's a lot of expectation on them to win the series convincingly.
"We have a young squad with an average age of 24 so we are still developing and improving. It'll be a great challenge for us and one we're looking forward to meeting head on."
England: 15 Mike Brown, 14 Anthony Watson, 13 Jonathan Joseph, 12 Luther Burrell, 11 Marland Yarde, 10 Owen Farrell, 9 Ben Youngs, 8 Billy Vunipola, 7 James Haskell, 6 Chris Robshaw, 5 George Kruis, 4 Maro Itoje, 3 Dan Cole, 2 Dylan Hartley (captain), 1 Mako Vunipola.
Replacements: 16 Luke Cowan-Dickie, 17 Matt Mullan, 18 Paul Hill, 19 Joe Launchbury, 20 Courtney Lawes, 21 Danny Care, 22 George Ford, 23 Jack Nowell.
Date: Saturday, June 11
Venue: Suncorp Stadium, Brisbane
Kick-off: 20.05 AEST (11.05 UK time; 10.05 GMT)
Referee: Romain Poite (France)
Assistant referees: Craig Joubert (South Africa), Glen Jackson (New Zealand)
