Gatland picks stalwarts for England
Prop Gethin Jenkins will play in his fourth World Cup after being named in Wales’ starting line-up.
Jenkins will make his 16th appearance in the game's showpiece tournament and will line-up alongside Scott Baldwin and Tomas Francis in the front row. Bradley Davies and Alun Wyn Jones will pack down in the second row.
Captain Sam Warburton will pack down in an all British and Irish Lions back row with Dan Lydiate and Taulupe Faletau.
Gareth Davies and Dan Biggar are named at scrumhalf and flyhalf respectively with Jamie Roberts and Scott Williams partnering in the centre.
The back three sees Liam Williams at fullback with George North and Hallam Amos. Amos is preffered to the experienced Alex Cuthbert, who drops to the replacements bench after a series of disappointing performances.
There is no place for experienced scrumhalf Mike Phillips in the matchday 23 who was called up when first-choice scrumhalf Rhys Webb was ruled out of the tournament before it got underway.
"Saturday is a huge occasion for both teams and for the tournament and we are really looking forward to it," said Wales head coach Warren Gatland.
"Both sides kicked their tournament off with a bonus-point win but we know we will need to step up at Twickenham on Saturday.”
England and Wales – who both still have two-time champions Australia to play in their Pool of Death – won their opening matches against Fiji and Uruguay respectively.
Ken Owens, Aaron Jarvis and Samson Lee are the front row replacements, with Luke Charteris and Justin Tipuric completing the forwards contingent. Lloyd Williams, Rhys Priestland and Alex Cuthbert are named as the backs replacements.
Wales: 15 Liam Williams, 14 George North, 13 Scott Williams, 12 Jamie Roberts, 11 Hallam Amos, 10 Dan Biggar, 9 Gareth Davies, 8 Taulupe Faletau, 7 Sam Warburton (captain), 6 Dan Lydiate, 5 Alun Wyn Jones, 4 Bradley Davies, 3 Tomas Francis, 2 Scott Baldwin, 1 Gethin Jenkins
Replacements: 16 Ken Owens, 17 Aaron Jarvis, 18 Samson Lee, 19 Luke Charteris, 20 Justin Tipuric, 21 Lloyd Williams, 22 Rhys Priestland, 23 Alex Cuthbert.
Date: Saturday, September 26
Venue: Twickenham Stadium, London
Kick-off: 20.00 (19.00 GMT)
Referee: Jérôme Garcès (France)
Assistant referees: Romain Poite (France), Mathieu Raynal (France)
TMO: Shaun Veldsman (South Africa)