Uncapped duo in Ireland team for England
The defending champions, Ireland, are looking to revive their campaign.
Ireland coach Joe Schmidt made five changes to the starting team beaten 10-9 by France last time out.
Powerful centre McCloskey was picked in place of injured Ulster teammate Jared Payne, while Van der Flier comes in for Sean O'Brien (hamstring) at openside flank.
Keith Earls starts on the left wing in place of the sidelined Dave Kearney, with lock Donnacha Ryan taking over from concussion victim Mike McCarthy in the second row.
But there was better news for Ireland at tighthead prop, with the experienced Mike Ross fit again following hamstring trouble.
Ireland, bidding for a third straight title, have yet to win in this season's Six Nations after opening their campaign with a 16-all draw at home to Wales and then the loss to France.
Date: Saturday, February 27
Venue: Twickenham Stadium, London
Kick-off: 16.50 (16.50 GMT)
Referee: Romain Poite (France)
Assistant referees: Nigel Owens (Wales), Alexandre Ruiz (France)
TMO: Shaun Veldsman (South Africa)
Agence France-Presse
