Watson, Vunipola return for England
In the back line Jonathan Joseph (Bath) is reinstated at outside centre, Jack Nowell (Exeter Chiefs) is named on the right wing and Ben Youngs (Leicester Tigers) starts at scrumhalf.
Anthony Watson (Bath) and Billy Vunipola (Saracens) return to an England match-day 23 for the first time in this year's Championship having both returned from injury.
They are joined by Danny Care (Harlequins) and Ben Te'o (Worcester Warriors) in the only other changes to the bench.
Saturday's match will see 26-year old loosehead prop Joe Marler (Harlequins) win his 50th cap for England having made his debut against South Africa at Kings Park Stadium in Durban in 2012.
To mark the milestone Marler will lead the team out of the tunnel for England's 124th Calcutta Cup game.
"Our preparation for Scotland has been very good," said England head coach Jones. "We had two excellent training runs in Oxford last week and followed that up this week.
"We're focused on ourselves; we want to give our fans a really good performance. We've worked hard in this Six Nations and feel like a good performance is just around the corner.
"This is the 124th Calcutta Cup and I feel humbled and honoured to be part of such an historic rugby occasion, it's the oldest international fixture and means a lot to both countries. We treasure the experience.
"I congratulate Joe Marler on his 50-cap milestone. I've coached a lot of good players and he is certainly one of the best. He is an honest and committed team man and a fine individual. To have him and Mako Vunipola available together to give us 80 minutes at loose-head is an enormous advantage."
England: 15 Mike Brown, 14 Jack Nowell, 13 Jonathan Joseph, 12 Owen Farrell, 11 Elliot Daly, 10 George Ford, 9 Ben Youngs, 8 Nathan Hughes, 7 James Haskell, 6 Maro Itoje, 5 Courtney Lawes, 4 Joe Launchbury, 3 Dan Cole, 2 Dylan Hartley (captain), 1 Joe Marler.
Replacements: 16 Jamie George, 17 Mako Vunipola, 18 Kyle Sinckler, 19 Tom Wood, 20 Billy Vunipola, 21 Danny Care, 22 Ben Te'o, 23 Anthony Watson.
Date: Saturday, March 11
Venue: Twickenham Stadium, London
Kick-off: 16.00 (16.00 GMT)
Referee: Mathieu Raynal (France)
Assistant referees: Romain Poite (France), Marius Mitrea (Italy)
TMO: Ben Skeen (New Zealand)
