Fofana recalled as France change 13
Fofana missed the opening 32-10 win over Italy because of a groin injury.
The 27-year-old Clermont ace is one of 13 changes to the starting XV against Italy.
No.8 Louis Picamoles and Fiji-born wing Noa Nakaitaci are the two survivors.
Hooker Dimitri Szarzewski captains the side which also features a halfback pairing of Remi Tales at flyhalf and experienced scrumhalf Morgan Parra.
France coach Philippe Saint-Andre said he was looking for a good all round performance and not 15 players seeking to press their own case.
"Wednesday's match is very important for the team performance," said Saint-Andre.
"I don't want 15 players just playing for themselves."
Saint-Andre, who steps down after the campaign is over following an underwhelming reign since the 2011 World Cup, said that despite Romania's lowly world ranking, France would not take victory for granted.
Roman are 17th in the world rankings, 10 places below France.
"We can beat anybody but we must not let our guard down against any side, including Romania."
At a shade under 28 years of age on average, France's team is their youngest in a World Cup match since their 87-10 win against Namibia eight years ago.
Frederic Michalak has been named on the bench but if he comes on and scores three points, he will break Thierry Lacroix's RWC points record for France. Michalak has currently scored 122 points.
France and Ireland top the Pool after winning their first games — the Irish whipping Canada 50-5 — with their likely table-topping decider the final pool game in Cardiff on October 11.
France: 15 Brice Dulin, 14 Sofiane Guitoune, 13 Gael Fickou, 12 Wesley Fofana, 11 Noa Nakaitaci, 10 Remi Tales, 9 Morgan Parra, 8 Louis Picamoles, 7 Fulgence Ouedraogo, 6 Yannick Nyanga, 5 Alexandre Flanquart, 4 Bernard Le Roux, 3 Uini Atonio, 2 Dimitri Szarzewski (captain), 1 Vincent Debaty.
Replacements: 16 Benjamin Kayser, 17 Eddy Ben Arous, 18 Nicolas Mas, 19 Yoann Maestri, 20 Damien Chouly, 21 Rory Kockott, 22 Frederic Michalak, 23 Mathieu Bastareaud.
Date: Wednesday, September 23
Venue: Olympic Park, London
Kick-off 20.00 (19.00 GMT, 21.00 French time, 22.00 Romanian time)
Referee: Jaco Peyper (South Africa)
Assistant referees: Craig Joubert (South Africa), Federico Anselmi (Argentina)
TMO: George Ayoub (Australia)
Agence France-Presse
