Romania's most experienced team ever
He has made eight changes to the starting line-up that lost 11-38 to France on Wednesday.
Flyhalf Michael Wiringi will make his World Cup debut.
However, Romania will still unleash their most experienced World Cup team of all time, with 710 caps in their starting line-up.
The starting XV is also Romania's oldest in a World Cup match, with an average age of 29 years 313 days.
The team's test record of 720 caps was set in the 13-18 defeat to Japan in November 2014.
Catalin Fercu is still just one try short of becoming Romania’s record try-scorer.
He has been stuck on 28 tries for 17 tests stretching back more than two years.
Romania: 15 Catalin Fercu, 14 Adrian Apostol, 13 Paula Kinikinilau, 12 Csaba Gal, 11 Ionut Botezatu, 10 Michael Wiringi, 9 Valentin Calafeteanu, 8 Daniel Carpo, 7 Mihai Macovei (captain), 6 Viorel Lucaci, 5 Ovidiu Tonita, 4 Valentin Poparlan, 3 Paulica Ion, 2 Andrei Radoi, 1 Andrei Ursache
Replacements: 16 Otar Turashvili, 17 Mihaita Lazar, 18 Alexandru Tarus, 19 Johannes van Heerden, 20 Stelian Burcea, 21 Florin Surugiu, 22 Florin Ionita, 23 Florin Vlaicu
Date: Sunday, September 27
Venue: Wembley Stadium, London
Kick-off: 16.45 (15.45 GMT, 18.45 EEST)
Referee: Craig Joubert (South Africa)
Assistant referees: Romain Poite (France), Leighton Hodges (Wales)
TMO: Shaun Veldsman (South Africa)
Source: @WorldRugby