Stander gets first Ireland start
Standers is the only new cap in the starting XV.
Ireland coach Joe Schmidt was left counting a mounting injury toll, with star flank Sean O'Brien and fullback Rob Kearney ruled out.
Rory Best wins his 90th cap as he assumes the captain's role and is joined in the front row by Jack McGrath and Nathan White.
Only the new skipper, Best, No.8 Jamie Heaslip and lock Devin Toner have retained their starting berths from Ireland's 43-20 World Cup quarterfinal defeat to Argentina.
Munster back row forward Stander will start at blindside, the 23-year-old having completed his Ireland qualification on residency grounds.
Leinster duo O'Brien and Kearney have both failed to beat hamstring trouble in time to face Wales, so Tommy O'Donnell slots in at openside flank and Simon Zebo at fullback.
O'Brien and Kearney sat out training on Friday, but Ireland will hope to have two of their most experienced men fit in time for the second-round clash against France in Paris.
Flank O'Donnell dislocated his hip in Ireland's 35-21 warm-up victory over Wales in Cardiff in August.
The 28-year-old has hit back to fitness and form with Munster however, and will be a popular selection among Ireland's squad given his bad injury luck in missing the World Cup.
Even leaving aside former captain Paul O'Connell, now retired from Test rugby, Ireland are still shorn of six regulars in their pack this weekend.
Props Cian Healy and Mike Ross, lock Iain Henderson, and flanks Peter O'Mahony and Chris Henry join O'Brien on the treatment table.
Stander's debut has been accelerated due to O'Mahony's absence, but the former South African Under-20 star has excelled in his three years with Munster.
The Thomond Park province's European Champions Cup captain would have risen to Test prominence earlier had he not had to bide his time for residency qualification.
Kearney's absence in the backline hands Munster's livewire attacking talent Zebo a chance to impress, with Schmidt refusing to stray from a tried and tested midfield line-up.
Schmidt has restored his preferred midfield partnership of Robbie Henshaw and Jared Payne, refusing the temptation to pitch bullish Ulster centre Stuart McCloskey in for a Test debut.
With Tommy Bowe and Luke Fitzgerald both long-term absentees, Keith Earls partners Andrew Trimble on the wings.
Date: Sunday, February 7
Venue: Aviva Stadium, Dublin
Kick-off: 15.00 (15.00 GMT)
Referee: Jérôme Garcès (France)
Assistant referees: Glen Jackson (New Zealand), Ben O'Keeffe (New Zealand)
TMO: Graham Hughes (England)
