All Blacks lose duo ahead of Wales clash
Wing Ioane – nominated for World Rugby's Player of the Year award last week – played the full 80 minutes as the All Blacks edged Scotland 22-17 at Murrayfield on Saturday.
However, a shoulder issue will see him miss next weekend's trip to Cardiff, while lock Romano, who was replaced early in the second half in Edinburgh, has a foot injury.
Wales, meanwhile, could be without influential back Liam Williams, who was withdrawn just short of the hour mark in a 13-6 victory over Georgia.
Williams was the only man to start against Georgia who had also been part of the XV against Australia a week earlier.
"I'm not sure about Liam Williams," coach Warren Gatland said of Williams. "He is hobbling around."