| | FIXTURE | VENUE | GMT | LOCAL | POOL |
| | Fri, 14 January 2022 |
| | Blue Bulls v Pumas | Mbombela Stadium | 17:00 | 19:00 | Round 1 |
| |
| | Sat, 15 January 2022 |
| | Griquas v Cheetahs | Toyota Stadium | 12:30 | 14:30 | Round 1 |
| | Golden Lions v Western Province | DHL Stadium | 15:00 | 17:00 | Round 1 |
| |
| | Wed, 19 January 2022 |
| | Pumas v Golden Lions | Emirates Airline Park | 13:30 | 15:30 | Round 2 |
| | Griquas v Sharks XV | Kings Park Stadium | 15:45 | 17:45 | Round 2 |
| | Blue Bulls v Western Province | DHL Stadium | 18:00 | 20:00 | Round 2 |
| |
| | Wed, 2 February 2022 |
| | Pumas v Griquas | Tafel Lager Park | 13:30 | 15:30 | Round 3 |
| | Cheetahs v Blue Bulls | Loftus Versfeld | 15:45 | 17:45 | Round 3 |
| | Western Province v Sharks XV | Kings Park Stadium | 18:00 | 20:00 | Round 3 |
| |
| | Fri, 18 February 2022 |
| | Western Province v Griquas | Tafel Lager Park | 17:00 | 19:00 | Round 4 |
| |
| | Sat, 19 February 2022 |
| | Cheetahs v Pumas | Mbombela Stadium | 12:30 | 14:30 | Round 4 |
| | Sharks XV v Golden Lions | Emirates Airline Park | 15:00 | 17:00 | Round 4 |
| |
| | Fri, 4 March 2022 |
| | Sharks XV v Pumas | Mbombela Stadium | 17:00 | 19:00 | Round 5 |
| |
| | Sat, 5 March 2022 |
| | Blue Bulls v Griquas | Tafel Lager Park | 12:30 | 14:30 | Round 5 |
| | Golden Lions v Cheetahs | Toyota Stadium | 15:00 | 17:00 | Round 5 |
| |
| | Wed, 16 March 2022 |
| | Golden Lions v Griquas | Tafel Lager Park | 13:30 | 15:30 | Round 6 |
| | Western Province v Cheetahs | Toyota Stadium | 15:45 | 17:45 | Round 6 |
| | Sharks XV v Blue Bulls | Loftus Versfeld | 18:00 | 20:00 | Round 6 |
| |
| | Wed, 23 March 2022 |
| | Pumas v Western Province | DHL Stadium | 13:00 | 15:00 | Round 7 |
| | Cheetahs v Sharks XV | Kings Park Stadium | 15:45 | 17:45 | Round 7 |
| | Blue Bulls v Golden Lions | Emirates Airline Park | 18:00 | 20:00 | Round 7 |
| |
| | Wed, 6 April 2022 |
| | Golden Lions v Pumas | Mbombela Stadium | 13:30 | 15:30 | Round 8 |
| | Sharks XV v Griquas | Tafel Lager Park | 15:45 | 17:45 | Round 8 |
| | Western Province v Blue Bulls | Loftus Versfeld | 18:00 | 20:00 | Round 8 |
| |
| | Thu, 14 April 2022 |
| | Griquas v Golden Lions | Emirates Airline Park | 13:00 | 15:00 | Round 9 |
| |
| | Fri, 15 April 2022 |
| | Cheetahs v Western Province | DHL Stadium | 14:45 | 16:45 | Round 9 |
| |
| | Fri, 6 May 2022 |
| | Pumas v Sharks XV | Kings Park Stadium | 14:45 | 16:45 | Round 10 |
| | Cheetahs v Golden Lions | Emirates Airline Park | 17:00 | 19:00 | Round 10 |
| |
| | Sat, 7 May 2022 |
| | Griquas v Blue Bulls | Tafel Lager Park | 15:00 | 17:00 | Round 10 |
| |
| | Fri, 13 May 2022 |
| | Western Province v Pumas | Mbombela Stadium | 17:00 | 19:00 | Round 11 |
| |
| | Sat, 14 May 2022 |
| | Sharks XV v Cheetahs | Toyota Stadium | 12:30 | 14:30 | Round 11 |
| | Golden Lions v Blue Bulls | Loftus Versfeld | 15:00 | 17:00 | Round 11 |
| |
| | Fri, 27 May 2022 |
| | Pumas v Blue Bulls | Loftus Versfeld | 17:00 | 19:00 | Round 12 |
| |
| | Sat, 28 May 2022 |
| | Cheetahs v Griquas | Tafel Lager Park | 12:30 | 14:30 | Round 12 |
| | Western Province v Golden Lions | Emirates Airline Park | 15:00 | 17:00 | Round 12 |
| |
| | Fri, 3 June 2022 |
| | Griquas v Western Province | Danie Craven Stadium | 14:00 | 16:00 | Round 13 |
| | Pumas v Cheetahs | Toyota Stadium | 16:00 | 18:00 | Round 13 |
| |
| | Sat, 4 June 2022 |
| | Golden Lions v Sharks XV | Kings Park Stadium | 15:00 | 17:00 | Round 13 |
| |
| | Fri, 10 June 2022 |
| | Sharks XV v Western Province | DHL Stadium | 14:00 | 16:00 | Round 14 |
| | Griquas v Pumas | Mbombela Stadium | 16:00 | 18:00 | Round 14 |
| |
| | Sat, 11 June 2022 |
| | Blue Bulls v Cheetahs | Toyota Stadium | 15:45 | 17:45 | Round 14 |
| |
| | Fri, 17 June 2022 |
| | Griquas v Blue Bulls | Loftus Versfeld | 17:00 | 19:00 | Round Semi Final |
| |
| | Sat, 18 June 2022 |
| | Pumas v Cheetahs | Toyota Stadium | 11:30 | 13:30 | Round Semi Final |
| |
| | Sat, 25 June 2022 |
| | Pumas v Griquas | Windhoek Draught Park | 13:00 | 15:00 | Round Final |
