Western Province make six changes
Dillyn Leyds will start at fullback – in place of the injured Cheslin Kolbe – with Kobus van Wyk moving up from the bench to start in the No.14 jersey.
In the final change to the Province backline this week, Springbok scrumhalf Jano Vermaak will make his first start, having come off the bench last week to score a valuable try for his new team.
Loosehead prop Steven Kitshoff has not recovered from his chest niggle, handing Oli Kebble a start in the No.1 jersey.
In the second row, Jan de Klerk will make a first start at this level, with Jean Kleyn getting a deserved rest on the bench.
Nizaam Carr returns to the starting XV to assume the captaincy and the No.8 jersey.
Sikhumbuzo Notshe, who started at No.8 last week, will move to the the side of the scrum at No.7
Jurie van Vuuren, a last-minute starter last weekend, reverts to the bench.
The hard-hitting Rynhardt Elstadt is still unavailable with a thigh injury.
The new faces on the bench this week are fit-again hooker Michael Willemse (in for the injured Siyabonga Ntubeni), prop Ali Vermaak and utility back Jaco Taute.
"Jan de Klerk deserves a start in the No.4 jersey and we have a plan with Jean Kleyn in the second half," said the coach.
"Unfortunately, Steven Kitshoff will join Scarra [Siyabonga] Ntubeni, Rynhardt Elstadt and Cheslin Kolbe on the sidelines this week, but it gives Oli Kebble a big opportunity on the loosehead side.
"This match is hugely important for us in terms of our home semifinal hopes, so it's good to have our captain Nizaam Carr back and we're keen to see how Jano Vermaak goes in his first start.
"On the whole, I am looking for a big improvement – as I said last week – in terms of our discipline and sustained attack."
Western Province: 15 Dillyn Leyds, 14 Kobus van Wyk, 13 Johnny Kotze, 12 Huw Jones, 11 Seabelo Senatla, 10 Robert du Preez, 9 Jano Vermaak, 8 Nizaam Carr (captain), 7 Sikhumbuzo Notshe, 6 Chris Cloete, 5 Ruan Botha, 4 Jan de Klerk, 3 Wilco Louw, 2 Mbongeni Mbonambi, 1 Oli Kebble.
Replacements: 16 Michael Willemse, 17 Ali Vermaak, 18 Jean Kleyn, 19 Jurie van Vuuren, 20 Nic Groom, 21 Demetri Catrakilis, 22 Jaco Taute.
Date: Saturday, September 24
Venue: Newlands, Cape Town
Kick-off: 15.00 (13,00 GMT)
Referee: Cwengile Jadezweni
Assistant referees: Marius van der Westhuizen, Divan Uys