Wyles leads USA into battle
Influential leader Wyles plays his club rugby for Saracens in the Premiership and is not shy of experience on the big stage.
In the midfield Thretton Palamo, who made his World Cup debut in 2007 as the tournament's youngest player, cuts coach Mike Tolkin's side and will be partnered up with Seamus Kelly in the centres.
Takudzwa Ngwenya, the player who will always be remembered for burning Springbok wing Bryan Habana in the 2007 World Cup, is named at right wing.
In the forwards, blockbusting No.8 Sam Manoa will form a looseforward trio with Andrew Durutalo and Al McFarland while Eric Fry, Zach Fenoglio and Titi Lamositele will anchor the scrum in the front row.
USA: 15 Blaine Scully, 14 Takudzwa Ngwenya, 13 Seamus Kelly, 12 Thretton Palamo, 11 Chris Wyles (captain), 10 AJ MacGinty, 9 Mike Petri, 8 Samu Manoa, 7 Andrew Durutalo, 6 Al McFarland, 5 Greg Peterson, 4 Hayden Smith, 3 Titi Lamositele, 2 Zach Fenoglio, 1 Eric Fry.
Replacements: 16 Phil Thiel, 17 Oli Kilifi, 18 Chris Baumann, 19 Cam Dolan, 20 Danny Barrett, 21 Shalom Suniula, 22 Folau Niua, 23 Brett Thompson.
Date: Saturday, September 19
Venue: Brighton Community Stadium, Brighton
Kick-off: 12.00 (11.00 GMT; 07.00 American Eastern Time; Monday September 21, 00.00 Samoa Time)
Referee: George Clancy (Ireland)
Assistant referees: Jaco Peyper (South Africa), Federico Anselmi (Argentina)
TMO: Graham Hughes (England)