Dempsey to make Wallabies debut
Dempsey, who travelled on the 2016 Spring Tour as a Development Player, is set to become Wallaby 909 and the sixth debutant so far this season.
Wallabies coach Michael Cheika has again opted for a five-three split on the bench with Tatafu Polota-Nau, Toby Smith and Sam Carter the other changes to the reserves.
The last time the Wallabies met Italy in Brisbane, George Gregan made his International debut, in a tense 23-20 win at Ballymore in 1994.
Australia: 15 Israel Folau, 14 Dane Haylett-Petty, 13 Rob Horne, 12 Karmichael Hunt, 11 Sefa Naivalu, 10 Bernard Foley, 9 Will Genia, 8 Lopeti Timani, 7 Michael Hooper, 6 Ned Hanigan, 5 Adam Coleman, 4 Rory Arnold, 3 Allan Alaalatoa, 2 Stephen Moore (captain), 1 Scott Sio.
Replacements: 16 Tatafu Polota-Nau, 17 Toby Smith, 18 Sekope Kepu, 19 Sam Carter, 20 Jack Dempsey, 21 Joe Powell, 22 Quade Cooper, 23 Reece Hodge.
Date: Saturday, June 24
Venue: Suncorp Stadium, Brisbane
Kick-off: 15.00 (07.00 Italy time; 05.00 GMT)
Referee: Matthew Carley (England)
Assistant referees: Wayne Barnes (England), Brendon Pickerill (New Zealand)
TMO: Ben Skeen (New Zealand)