Moore gets a start in swan song
It will be the 34-year old's 97th Test start and eighth match against Scotland – with the hooker set to retire from all forms of the game following Saturday's clash.
While it will mark the end for the former captain, it's just the beginning for 21-year old Taniela Tupou.
The tighthead prop, known widely as 'the Tongan Thor', is set to make his long-awaited Test debut after completing his three-year residency requirement.
Fellow Queenslander Lukhan Tui will also return from injury via the bench, after suffering a hamstring strain against the Barbarians a month ago.
Scotland reclaimed the Hopetoun Cup in June of this year after a 24-19 win over the Wallabies in Sydney.
It's been a tight recent record between Australia and Scotland – with three wins apiece over the last six games, while just seven points have split the two sides in their last three meetings.
Australia: 15 Kurtley Beale, 14 Marika Koroibete, 13 Tevita Kuridrani, 12 Samu Kerevi, 11 Reece Hodge, 10 Bernard Foley, 9 Will Genia, 8 Sean McMahon, 7 Michael Hooper (captain), 6 Ben McCalman, 5 Blake Enever, 4 Rob Simmons, 3 Sekope Kepu, 2 Stephen Moore, 1 Scott Sio.
Replacements: 16 Tatafu Polota-Nau, 17 Tetera Faulkner, 18 Taniela Tupou, 19 Lukhan Tui, 20 Lopeti Timani, 21 Nick Phipps, 22 Karmichael Hunt, 23 Henry Speight.
Date: Saturday, November 25
Venue: Murrayfield, Edinburgh
Kick-off: 14.30 (14.30 GMT; 01.30, Sunday, November 26, AEDT)
Referee: Pascal Gaüzère (France)
Assistant referees: John Lacey (Ireland), David Wilkinson (Ireland)
TMO: Graham Hughes (England)