Three new Wallaby caps to face England
Brumbies lock Rory Arnold, Reds centre Samu Kerevi and Western Force wing Dane Haylett-Petty will start the first of three Tests for the Cook Cup.
The 2.08 metre Arnold will become the tallest man to wear the Wallabies' gold jersey when he makes his debut alongside 60-Test veteran Rob Simmons at lock.
"This team has a great opportunity to build on the foundations in place," Cheika said at the team announcement.
"We have a good mix of new blood and players who have been connected to the group for some time and the energy and enjoyment within the group has been excellent."
Reds outside back Kerevi will team up with Brumbies centre Tevita Kuridrani to form one of the biggest centre pairings for the Wallabies in an anticipated physical confrontation with England.
Haylett-Petty has secured a berth on the right wing with the team's newly appointed vice-captain Rob Horne on the left.
Cheika has named one more potential Test newcomer on the bench, with Reds scrumhalf Nick Frisby, while Christian Leali'ifano has been named in the 23-player squad following the birth of his son.
Newly re-signed Waratahs prop Sekope Kepu returns from French Top 14 club Bordeaux-Begles on the replacements bench alongside Harlequins lock and former Reds captain James Horwill.
Hooker Stephen Moore will play his 103rd Test when he leads the Wallabies for the 12th time, surpassing Stephen Larkham and Matt Giteau (both on 102 Test caps) to become the fourth-most capped Wallaby of all time.
Australia: 15 Israel Folau, 14 Dane Haylett-Petty, 13 Tevita Kuridrani, 12 Samu Kerevi, 11 Rob Horne, 10 Bernard Foley, 9 Nick Phipps, 8 David Pocock, 7 Michael Hooper, 6 Scott Fardy, 5 Rob Simmons, 4 Rory Arnold, 3 Greg Holmes, 2 Stephen Moore (captain), 1 Scott Sio.
Replacements: 16 Tatafu Polota-Nau, 17 James Slipper, 18 Sekope Kepu, 19 James Horwill, 20 Dean Mumm, 21 Sean McMahon, 22 Nick Frisby, 23 Christian Leali'ifano.
Date: Saturday, June 11
Venue: Suncorp Stadium, Brisbane
Kick-off: 20.05 AEST (11.05 UK time; 10.05 GMT)
Referee: Romain Poite (France)
Assistant referees: Craig Joubert (South Africa), Glen Jackson (New Zealand)
