Christian wading in for England
England will face the Barbarians in Sunday's non-cap international match at Twickenham with 11 players who featured in this year's Six Nations.
In a backline of Ben Foden, Chris Ashton, Brad Barritt and Lee Dickson, Owen Farrell moves to inside centre and Charlie Hodgson returns at No.10.
London Wasps flier Christian Wade – second highest try scorer in the Premiership this season (nine in 15 games) – gets his chance on the left wing.
Dylan Hartley and Mouritz Botha, who started against Ireland in the final game of the Six Nations, are named, while Phil Dowson captains the side from the back row alongside Exeter Chiefs' Tom Johnson and Bath's Carl Fearns.
England Head Coach Stuart Lancaster said they are treating this as a "very important" game for setting the foundations for the three-Test tour to South Africa next month.
"The players have been excellent this week and have been fully focussed as we are looking to build on the momentum of the Six Nations. This is a really important milestone in our preparation for South Africa.
"With the Leicester and Harlequins players unavailable it's a great opportunity for those other players involved in the Six Nations to lead the way.
"Some of the younger players have a chance to put a marker down and get their first taste of international rugby such as Christian Wade on the wing, Joe Launchbury, Alex Goode and Jonathan Joseph on the bench.
"Being able to name a back line very similar to the Six Nations and the strength we have in the forwards with the likes of Tom Johnson and Carl Fearns, who played in this game last year, is a real positive.
"The support we had at Twickenham against Wales and Ireland was fantastic and we can't wait to get back there. The Barbarians have a really strong team packed with talent and experience and having been involved in this fixture before I know it will be a great occasion."
England: 15 Ben Foden, 14 Chris Ashton, 13 Brad Barritt, 12 Owen Farrell, 11 Christian Wade, 10 Charlie Hodgson, 9 Lee Dickson, 8 Phil Dowson (captain), 7 Carl Fearns, 6 Tom Johnson, 5 Tom Palmer, 4 Mouritz Botha, 3 Paul Doran Jones, 2 Dylan Hartley, 1 Matt Stevens.
Replacements: 16 Lee Mears, 17 Matt Mullan, 18 Joe Launchbury, 19 Jamie Gibson, 20 Richard Wigglesworth, 21 Jonathan Joseph, 22 Alex Goode.
Date: Sunday, May 27
Kick-off: 14.30 (13.30 GMT)
Venue: Twickenham, London
Referee: John Lacey (Ireland)
Assistant referees: Peter Fitzgibbon (Ireland), Simon McDowell (Ireland)