England move closer to Six Nations title
But England, 16-0 up at the break and leading 22-7 early in the second half, had to endure an anxious finish as Wales scored two converted tries in four minutes near full-time through George North and Taulupe Faletau.
Saracens lock Itoje, given his Test debut this season by new England coach Eddie Jones, had a superb all-round match as the home side gained a measure of revenge for their World Cup defeat by Wales.
England had a commanding half-time lead thanks to Anthony Watson's converted try, from a move Itoje initiated, and three Owen Farrell penalties.
Flyhalf Dan Biggar eventually got Wales on the scoreboard with a converted try.
But, with Farrell adding three more penalties, North and Faletau's scores after England prop Dan Cole was yellow-carded came too late to deny England a win that was effectively sealed when the returning Manu Tuilagu forced North into touch in the dying seconds.
Wales outscored England three tries to one but England's victory made it four wins out of four under Australian boss Jones and ended Wales' title hopes.
It also meant England had claimed the Triple Crown and they will have their first Six Nations title since 2011 with a round to spare if Scotland beat France at Murrayfield on Sunday.
Even if that result goes against them, England can still win the Championship and claim a first Grand Slam since their World Cup-winning year of 2003 if they beat France in Paris next Saturday.
When England and Wales last met, the Welsh had come back from a 10-point deficit to win 28-25 in a World Cup pool match at Twickenham in September – a result that played a major part in hosts England's first-round exit.
England's matchday 23 contained 13 survivors from that loss and one of them, Mike Brown, almost scored an early try.
However, the fullback cut inside when he might have gone for the corner and was tackled short of the tryline by Biggar.
At that stage England No.8 Billy Vunipola was outplaying childhood friend and Wales counterpart Faletau.
England soon attacked again and won a penalty that Farrell kicked for a 3-0 lead.
They then laid siege to the Welsh line.
Prop Dan Cole crossed but, with the grounding deemed inconclusive on replay, no try was awarded.
Jones had accused Wales of "illegal" scrummaging in the build-up, and from the ensuing five-metre home set piece, South African referee Craig Joubert ruled Wales had infringed.
Farrell kicked a simple penalty and then landed a longer-range effort in the 20th minute to make it 9-0.
Wales kicked a penalty for an attacking line-out but Itoje, winning just his third cap, stole the ball off their throw.
The try England had threatened came in the 31st minute after Itoje burst through a couple of tackles off a ruck and fed Brown, who had Watson on his shoulder and a well-timed pass sent the wing in at the left corner.
Wales needed a score but great ruck defence, with Itoje again prominent, saw England win a relieving penalty near their own line.
Farrell's early second-half penalty extended England's advantage to 19-0.
By contrast, penalties were no longer an option for Wales.
They pressed hard for a try off a couple of close-range scrums but England's defence held firm only for Biggar to charge down opposing flyhalf George Ford's kick and run in under the posts for a try he duly converted.
But Wales then saw captain Sam Warburton carried off after a clash with England flank James Haskell.
England ended Tuilagi's 21-month, largely injury-induced, Test exile by bringing the centre off the bench and Farrell kicked two more penalties.
Cole was sin-binned inside the final 10 minutes, leading to a Welsh onslaught.
Giant wing North burst clear down the left in the 74th minute and set up Faletau's try three minutes later but England held out.
Man of the match: Owen Farrell's boot was key to the English victory. He scored 20 of his team's points. Anthony Watson was a livewire on the wing, while fullback Mike Brown got over the advantage line every time he got the ball. For Wales, George North was at his absolute best. He beat defenders with his pace and strength and got a crucial try for his team as well. However, our award goes to Maro Itoje. The lock made more tackles than any other player in his team and also carried the ball over the advantage line on a number of occasions. He was awesome in the line-outs as well, stealing a few balls on the Welsh throw-in.
Moment of the match: Dan Cole's yellow card in the 71st minute gave the Welsh hope in that final ten minutes – the visitors scoring two tries in the period he was off.
Villain of the match: There was nothing really villainous in this game, although something could be said about Tomas Francis' fingers going incredibly close to Dan Cole's eyes at the bottom of a ruck.
The scorers:
For England:
Try: Watson
Con: Farrell
Pens: Farrell 6
For Wales:
Tries: Biggar, North, Faletau
Cons: Biggar, Priestland 2
Yellow card: Dan Cole (England, 71 – reapeated infringements, collapsing the maul)
Teams:
England: 15 Mike Brown, 14 Anthony Watson, 13 Jonathan Joseph, 12 Owen Farrell, 11 Jack Nowell, 10 George Ford, 9 Ben Youngs, 8 Billy Vunipola, 7 James Haskell, 6 Chris Robshaw, 5 George Kruis, 4 Maro Itoje, 3 Dan Cole, 2 Dylan Hartley (captain), 1 Joe Marler.
Replacements: 16 Luke Cowan-Dickie, 17 Mako Vunipola, 18 Kieran Brookes, 19 Courtney Lawes, 20 Jack Clifford, 21 Danny Care, 22 Manu Tuilagi, 23 Elliot Daly.
Wales: 15 Liam Williams, 14 Alex Cuthbert, 13 Jonathan Davies, 12 Jamie Roberts, 11 George North, 10 Dan Biggar, 9 Gareth Davies, 8 Taulupe Faletau, 7 Sam Warburton (captain), 6 Dan Lydiate, 5 Alun Wyn Jones, 4 Bradley Davies, 3 Samson Lee, 2 Scott Baldwin, 1 Rob Evans.
Replacements: 16 Ken Owens, 17 Paul James, 18 Tomas Francis, 19 Luke Charteris, 20 Justin Tipuric, 21 Rhys Webb, 22 Rhys Priestland, 23 Gareth Anscombe.
Referee: Craig Joubert (South Africa)
Assistant Referees: Jérôme Garcès (France), Mathieu Raynal (France)
TMO: Ben Skeen (New Zealand)
Agence France-Presse & rugby365com
