Wales change one for Boks
Dan Lydiate comes into the side at blindside flank in place of Sam Warburton who picked up an injury in training on Tuesday.
There are two further changes amongst the replacements – with Taulupe Faletau returning from injury to take his place on the bench alongside Ospreys flyhalf Sam Davies.
Gethin Jenkins, who has led Wales in every match he has started this campaign, will lead the side and lines up in a front row alongside Ken Owens and Tomas Francis.
Luke Charteris and Alun Wyn Jones are named in the second row, with Lydiate lining up alongside Justin Tipuric and Ross Moriarty in the back row.
Gareth Davies (No.9) and Dan Biggar (No.10) are once against named at halfback, with Scarlets duo Scott Williams and Jonathan Davies in the midfield.
The same back three that faced Argentina is named – with Leigh Halfpenny at fullback and George North and Liam Williams on the wings.
"We were pleased with the win against Argentina so have gone with virtually the same team for South Africa," said coach Rob Howley.
"We've made just one change in the back row. Sam [Warburton] picked up a bit of a stinger injury on Tuesday and isn't quite ready so Dan comes in.
"Dan played particularly well against Japan so we are pleased he gets the opportunity again.
"It's good to have Taulupe back in the squad, he will add a good impact from the bench.
"We are delighted with Sam, he showed individual composure and accuracy last weekend and he gets another opportunity on the bench, as he did against Australia.
"There is the tinge of disappointment in terms of performance against Japan and we want to put that right. Not only are we looking to win this weekend we want a performance to go with it."
On the bench, Scott Baldwin, Nicky Smith and Samson Lee make up the front row replacements.
Cory Hill will look to win his third cap this weekend and is joined by Faletau who completes the forward line-up.
Lloyd Williams, Davies and Jamie Roberts provide the backline cover.
Wales: 15 Leigh Halfpenny, 14 George North, 13 Jonathan Davies, 12 Scott Williams, 11 Liam Williams, 10 Dan Biggar, 9 Gareth Davies, 8 Ross Moriarty, 7 Justin Tipuric, 6 Dan Lydiate, 5 Alun Wyn Jones, 4 Luke Charteris, 3 Tomas Francis, 2 Ken Owens, 1 Gethin Jenkins (captain).
Replacements: 16 Scott Baldwin, 17 Nicky Smith, 18 Samson Lee, 19 Cory Hill, 20 Taulupe Faletau, 21 Lloyd Williams, 22 Sam Davies, 23 Jamie Roberts.
Date: Saturday, November 26
Venue: Millennium Stadium, Cardiff
Kick-off: 17.30 (17.30 GMT; 19.30 SA time)
Referee: Matthew Carley (England)
Assistant referees: Mathieu Raynal (France), Dan Jones (Wales)
TMO: Simon McDowell (Ireland)
