Cruden to miss Montpellier's European opener
Cruden, 28-year-old, sustained a thigh injury in training on Thursday to scupper his comeback from a previous rib problem.
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The place of the 50-times capped New Zealander will be taken by Springbok utility player Francois Steyn.
Meanwhile, No.8 Louis Picamoles returns to skipper the side after missing the last three Top 14 games because of his own thigh injury.
Agence France-Presse