Powell rotates again ahead of Paris Sevens
They replace Siviwe Soyizwapi, Branco du Preez, Chris Dry and Stephan Dippenaar respectively from the side that won bronze in Singapore last month.
Hougaard returns to the Springboks Sevens team following a stint with Worcester Warriors and Snyman, who picked up a head-knock in Hong Kong, now fully fit and again takes over from Dry, who replaced him in Singapore.
The return of Specman, who last played in Vancouver, means that Du Preez misses out on the French tournament. Sage also last played in Vancouver and missed out in Hong Kong and Singapore when Dippenaar was given a run for the first time in the current series.
Powell explained that he is looking to rotate a number of players after Paris, with some changes expected again for the London Sevens in two weeks' time.
"It is important for us to do well and try and win the series, but we also need to look at the welfare of regulars with Rio in mind, so I am planning to replace a number of these guys travelling to Paris for the London tournament," Powell said.
"We have built good depth in the squad and with a number of players really pushing hard for a starting spot, I feel comfortable that we can rotate some players in the next two weeks and still remain very competitive. We came close on many occasions during the series and we need to keep on believing.
"It is going to be tough to overhaul Fiji at the top of the standings, but we are still in it with two tournaments to go. That was one of our objectives at the start of the 2015/16 series."
Powell is also expanding his captaincy base and called on Philip Snyman to lead the side. Snyman also took charge of the side in the Wellington and Sydney tournaments earlier this year.
"We are determined to do well," Snyman said. "We owe it to ourselves to finish strong, especially with the Olympics on the horizon. That said, the focus will be on game one, day one against England. We want to play well and make our supporters proud as well. We owe them so much."
South Africa is currently second on the overall log. Fiji (147 points) remains firm favourites to win the overall World Rugby Sevens Series for a second year in a row, but South Africa (139) and New Zealand (135) can still pip them at the post if the South Sea team falters in Europe.
The Blitzboks are grouped in Pool B with Australia, England and Brazil in Paris. They face England next Friday and Brazil and Australia on Saturday and will be looking for a ninth consecutive Cup quarterfinal berth come Sunday, May 15.
Springbok Sevens: Ryan Kankowski, Philip Snyman (captain), Tim Agaba, Albertus Smith, Francois Hougaard, Kyle Brown, Dylan Sage, Rosko Specman, Justin Geduld, Cecil Afrika, Seabelo Senatla, Ruhan Nel.