Care to make England history against Wales
Danny Care starts at scrumhalf and will become England's most capped No.9 (78), moving past 2003 Rugby World Cup winner Matt Dawson.
Jonathan Joseph comes in for Ben Te'o at outside centre.
Following an injury to Ben Youngs, Richard Wigglesworth has been named as a replacement. The 34-year-old Saracens scrumhalf last played for England in 2015.
"The team is hugely excited about playing in front of 82 000 fans at Twickenham and we'll be well prepared and ready to go out there and beat Wales on Saturday.
"We want to make sure our set piece is dominant, our defence is ferocious and that we are at our best against Wales this weekend."
Jones added: "Danny Care very much deserves the honour of being the most capped England scrumhalf and I am sure he'll make the most of his opportunity on Saturday."
England: 15 Mike Brown, 14 Anthony Watson, 13 Jonathan Joseph, 12 Owen Farrell, 11 Jonny May, 10 George Ford, 9 Danny Care, 8 Sam Simmonds, 7 Chris Robshaw, 6 Courtney Lawes, 5 Maro Itoje, 4 Joe Launchbury, 3 Dan Cole, 2 Dylan Hartley, 1 Mako Vunipola.
Replacements: 16 Jamie George, 17 Alec Hepburn, 18 Harry Williams, 19 George Kruis, 20 Sam Underhill, 21 Richard Wigglesworth, 22 Ben Te'o, 23 Jack Nowell.
Date: Saturday, February 10
Venue: Twickenham Stadium, London
Kick-off: 16.45 (16.45 GMT)
Referee: Jérôme Garcès (France)
Assistant referees: Mathieu Raynal (France), Nic Berry (Australia)
TMO: Glenn Newman (New Zealand)