Fife to fill the gap
Dougie Fife, the 23-year-old Edinburgh wing, becomes the second new cap of Scotland's 2014 Six Nations Championship campaign.
He was named in the team to play Wales in Cardiff on Saturday.
Fife, nurtured by the Boroughmuir and Currie clubs and the first former pupil of Firhill High School in Edinburgh to play for Scotland, replaces Tommy Seymour who has not recovered sufficiently from the ankle injury he sustained against France last weekend.
On the other wing Max Evans, who knows what it is to score a try at the Millennium Stadium, proved his fitness at training and will win his 42nd cap.
On the bench Jack Cuthbert will provide back three cover.
It's Cuthbert's first involvement in a Scotland matchday 23 since the final game in the 2012 Championship.
Scotland coach Scott Johnson is delighted to add Fife – Scotland's 1053rd cap – to join Chris Fusaro as a debutant during this campaign.
"We like Dougie's size and his competitive edge," Johnson said.
"He chases everything, which I like, and he has shown really good glimpses playing for Edinburgh this season.
"He's been ear-marked by us for a while – we've been following him for the last 12 months – and he's got his reward now. If he gets this one right, you might find that he puts a bit of pressure on [for a place] going forward, which is really good."
"I don't really think Saturday will faze Dougie. He's one of those players where it doesn't seem to matter who he marks he just goes out and plays the same."
Fife said: "I'm absolutely delighted and can't wait. The Millennium Stadium with the roof closed – I don't think it could be much better to be honest."
"When I got a run of games with Edinburgh and started doing fairly well I felt I could be on the brink [of a Scotland call] if I stuck in. Luckily I've been patient and my time has come."
Fife has visited the home of Welsh rugby before – on a tour with the Scotland Under-20 team – and is relishing the prospect of his debut this weekend.
Scotland: 15 Stuart Hogg, 14 Dougie Fife, 13 Alex Dunbar, 12 Matt Scott, 11 Max Evans , 10 Duncan Weir, 9 Greig Laidlaw, 8 David Denton, 7 Kelly Brown (captain), 6 Ryan Wilson, 5 Jim Hamilton, 4 Richie Gray, 3 Geoff Cross, 2 Scott Lawson, 1 Ryan Grant.
Replacements: 16 Ross Ford, 17 Alasdair Dickinson, 18 Euan Murray, 19 Tim Swinson, 20 Alasdair Strokosch, 21 Chris Cusiter, 22 Duncan Taylor, 23 Jack Cuthbert.
Date: Saturday, March 15
Venue: s Millennium Stadium, Cardiff
Kick-off: 14.45 (14.45 GMT)
Referee: Jérôme Garcès (France)
Assistant referees: Chris Pollock (New Zealand), Greg Garner (England)
TMO: Graham Hughes (England)
