De Jongh out with concussion
De Allende will partner Johnny Kotze in midfield after co-captain Juan de Jongh was ruled out due to a delayed concussion. Scrumhalf Nic Groom will play his 50th Super Rugby game for the Stormers in Saturday's match.
Frans Malherbe returns to the starting XV to lead the side in one of four rotational changes to the forward pack.
He is joined by Oli Kebble in the front row, with Vincent Koch and JC Janse van Rensburg named on the replacements bench.
Rynhardt Elstadt makes his first start of the season at lock, with JD Schickerling set to make an impact from the bench, whilst in the loose trio Schalk Burger makes way for Siyamthanda Kolisi, with Nizaam Carr moving to No.8.
Stormers head coach Robbie Fleck said that the team is looking forward to playing in front of their faithful fans at Newlands.
"Our philosphy this season is to keep growing and learning from our experiences, and it is important that we make another step up against a competitive Reds side.
"It is great to be back home at Newlands, and the team is focused on delivering a worthy performance," he said.
Stormers: 15 Cheslin Kolbe, 14 Kobus van Wyk, 13 Johnny Kotze, 12 Damian de Allende, 11 Leolin Zas, 10 Jean-Luc du Plessis, 9 Nic Groom, 8 Nizaam Carr, 7 Siyamthanda Kolisi, 6 Sikhumbuzo Notshe, 5 Pieter-Steph du Toit, 4 Rynhardt Elstadt, 3 Frans Malherbe (captain), 2 Mbongeni Mbonambi, 1 Oliver Kebble.
Replacements: 16 Mike Willemse, 17 JC Janse van Rensburg, 18 Vincent Koch, 19 JD Schickerling, 20 Schalk Burger, 21 Louis Schreuder, 22 Huw Jones, 23 Brandon Thomson.
Date: Saturday, April 23
Venue: Newlands, Cape Town
Kick-off: 15.00 (23.00 AEST; 13.00 GMT)
Referee: Marius van der Westhuizen
Assistant referees: Quinton Immelman, Cwengile Jadezweni
TMO: Shaun Veldsman