Dyantyi in shock Lions move
Aphiwe Dyantyi, who mostly featured on the wing for the Lions has been chosen to start in the No.13 jersey.
He will partner Rohan Janse van Rensburg in the midfield.
Madosh Tambwe and Sylvian Mahuza will be the wings for Saturday's clash.
Hacjivah Dayimani makes his way back into the starting line-up at No.8.
Springbok scrumhalf Ross Cronje has been included on the bench.
Meanwhile, Elton Jantjies will earn his 100th Super Rugby cap for the Lions.
Jantjies made his Super Rugby debut in 2011 and has nine tries, 112 conversions and 145 penalties under his belt.
Lions: 15 Andries Coetzee, 14 Sylvian Mahuza, 13 Aphiwe Dyantyi, 12 Rohan Janse Van Rensburg, 11 Madosha Michael Tambwe, 10 Elton Jantjies, 9 Nicholas Groom, 8 Hacjivah Dayimani, 7 Francois Mostert (captain), 6 Albertus Smith, 5 Marvin Orie, 4 Lourens Erasmus, 3 Ruan Dreyer, 2 Robbie Coetzee, 1 Dylan Smith.
Replacements: 16 Corne Fourie, 17 Jacques van Rooyen, 18 Johannes Jonker, 19 Len Massyn, 20 Marnus Schoeman, 21 Ross Cronje, 22 Shaun Reynolds, 23 Ruan Combrink.
Date: Saturday, May 19
Venue: Ellis Park, Johannesburg
Kick-off: 17.15 (15.15 GMT; 01.15 AEST Sunday, May 20)
Referee: Nick Briant (New Zealand)
Assistant referees: Quinton Immelman (South Africa), Stephen Geldenhuys (South Africa)
TMO: Marius Jonker (South Africa)