| | FIXTURE | VENUE | GMT | LOCAL | POOL |
| | Fri, 16 September 2022 |
| | Glasgow Warriors v Benetton Treviso | Stadio Comunale Di Monigo | 16:30 | 18:30 | Round 1 |
| |
| | Sat, 17 September 2022 |
| | Leinster v Zebre | Stadio Sergio Lanfranchi | 12:00 | 14:00 | Round 1 |
| | Munster v Cardiff Blues | Cardiff Arms Park | 14:05 | 16:05 | Round 1 |
| | Bulls v Lions | Emirates Airline Park | 14:05 | 16:05 | Round 1 |
| | Ospreys v Scarlets | Parc y Scarlets | 16:15 | 18:15 | Round 1 |
| | Gwent Dragons v Edinburgh | Dam Health Stadium | 18:35 | 20:35 | Round 1 |
| | Connacht v Ulster | Kingspan Stadium | 18:35 | 20:35 | Round 1 |
| |
| | Fri, 23 September 2022 |
| | Sharks v Zebre | Stadio Sergio Lanfranchi | 16:30 | 18:30 | Round 2 |
| | Cardiff Blues v Glasgow Warriors | Scotstoun Stadium | 18:35 | 20:35 | Round 2 |
| | Benetton Treviso v Leinster | RDS Arena | 18:35 | 20:35 | Round 2 |
| |
| | Sat, 24 September 2022 |
| | Ulster v Scarlets | Parc y Scarlets | 12:00 | 14:00 | Round 2 |
| | Edinburgh v Bulls | Loftus Versfeld | 12:30 | 14:30 | Round 2 |
| | Connacht v Stormers | Danie Craven Stadium | 12:30 | 14:30 | Round 2 |
| | Lions v Ospreys | Swansea RFC | 18:35 | 20:35 | Round 2 |
| |
| | Sun, 25 September 2022 |
| | Munster v Gwent Dragons | Rodney Parade | 14:00 | 16:00 | Round 2 |
| |
| | Fri, 30 September 2022 |
| | Connacht v Bulls | Loftus Versfeld | 16:30 | 18:30 | Round 3 |
| | Leinster v Ulster | Kingspan Stadium | 18:35 | 20:35 | Round 3 |
| | Lions v Cardiff Blues | Cardiff Arms Park | 18:35 | 20:35 | Round 3 |
| |
| | Sat, 1 October 2022 |
| | Edinburgh v Stormers | DHL Stadium | 12:00 | 14:00 | Round 3 |
| | Glasgow Warriors v Ospreys | Swansea RFC | 14:05 | 16:05 | Round 3 |
| | Zebre v Munster | Musgrave Park | 16:05 | 18:05 | Round 3 |
| | Scarlets v Benetton Treviso | Stadio Comunale Di Monigo | 16:15 | 18:15 | Round 3 |
| | Sharks v Gwent Dragons | Rodney Parade | 18:35 | 20:35 | Round 3 |
| |
| | Fri, 7 October 2022 |
| | Munster v Connacht | TBC | 18:35 | 20:35 | Round 4 |
| | Lions v Edinburgh | Dam Health Stadium | 18:35 | 20:35 | Round 4 |
| |
| | Sat, 8 October 2022 |
| | Stormers v Zebre | Stadio Sergio Lanfranchi | 14:00 | 16:00 | Round 4 |
| | Sharks v Leinster | RDS Arena | 16:05 | 18:05 | Round 4 |
| | Cardiff Blues v Scarlets | Parc y Scarlets | 16:15 | 18:15 | Round 4 |
| | Ospreys v Ulster | Kingspan Stadium | 18:35 | 20:35 | Round 4 |
| | Bulls v Glasgow Warriors | Scotstoun Stadium | 18:35 | 20:35 | Round 4 |
| |
| | Sun, 9 October 2022 |
| | Gwent Dragons v Benetton Treviso | Stadio Comunale Di Monigo | 13:45 | 15:45 | Round 4 |
| |
| | Fri, 14 October 2022 |
| | Stormers v Ospreys | Swansea RFC | 18:35 | 20:35 | Round 5 |
| | Leinster v Connacht | The Sportsground | 18:35 | 20:35 | Round 5 |
| |
| | Sat, 15 October 2022 |
| | Ulster v Lions | Emirates Airline Park | 12:00 | 14:00 | Round 5 |
| | Glasgow Warriors v Sharks | Kings Park Stadium | 14:05 | 16:05 | Round 5 |
| | Benetton Treviso v Edinburgh | Dam Health Stadium | 16:15 | 18:15 | Round 5 |
| | Gwent Dragons v Cardiff Blues | Cardiff Arms Park | 16:15 | 18:15 | Round 5 |
| | Bulls v Munster | Thomond Park | 18:35 | 20:35 | Round 5 |
| | Zebre v Scarlets | Parc y Scarlets | 18:35 | 20:35 | Round 5 |
| |
| | Fri, 21 October 2022 |
| | Bulls v Benetton Treviso | Stadio Comunale Di Monigo | 16:30 | 18:30 | Round 6 |
| | Scarlets v Connacht | The Sportsground | 18:35 | 20:35 | Round 6 |
| |
| | Sat, 22 October 2022 |
| | Edinburgh v Zebre | Stadio Sergio Lanfranchi | 12:00 | 14:00 | Round 6 |
| | Glasgow Warriors v Lions | Emirates Airline Park | 14:05 | 16:05 | Round 6 |
| | Ulster v Sharks | Kings Park Stadium | 16:15 | 18:15 | Round 6 |
| | Munster v Leinster | Aviva Stadium | 16:15 | 18:15 | Round 6 |
| | Stormers v Cardiff Blues | Cardiff Arms Park | 18:35 | 20:35 | Round 6 |
| |
| | Sun, 23 October 2022 |
| | Ospreys v Gwent Dragons | Rodney Parade | 14:00 | 16:00 | Round 6 |
| |
| | Sat, 29 October 2022 |
| | Leinster v Scarlets | TBC | 15:00 | 17:00 | Round 7 |
| | Ulster v Munster | TBC | 15:00 | 17:00 | Round 7 |
| | Benetton Treviso v Glasgow Warriors | TBC | 15:00 | 17:00 | Round 7 |
| | Zebre v Gwent Dragons | TBC | 15:00 | 17:00 | Round 7 |
| | Edinburgh v Cardiff Blues | TBC | 15:00 | 17:00 | Round 7 |
| | Connacht v Ospreys | TBC | 15:00 | 17:00 | Round 7 |
| |
| | Sun, 30 October 2022 |
| | Sharks v Bulls | TBC | 13:00 | 15:00 | Round 7 |
| |
| | Sat, 26 November 2022 |
| | Ospreys v Bulls | TBC | 15:00 | 17:00 | Round 8 |
| | Connacht v Munster | TBC | 15:00 | 17:00 | Round 8 |
| | Zebre v Ulster | TBC | 15:00 | 17:00 | Round 8 |
| | Gwent Dragons v Lions | TBC | 15:00 | 17:00 | Round 8 |
| | Glasgow Warriors v Leinster | TBC | 15:00 | 17:00 | Round 8 |
| | Edinburgh v Benetton Treviso | TBC | 15:00 | 17:00 | Round 8 |
| | Cardiff Blues v Sharks | TBC | 15:00 | 17:00 | Round 8 |
| | Scarlets v Stormers | TBC | 15:00 | 17:00 | Round 8 |
| |
| | Sat, 3 December 2022 |
| | Ospreys v Sharks | TBC | 15:00 | 17:00 | Round 9 |
| | Scarlets v Lions | TBC | 15:00 | 17:00 | Round 9 |
| | Glasgow Warriors v Zebre | TBC | 15:00 | 17:00 | Round 9 |
| | Benetton Treviso v Connacht | TBC | 15:00 | 17:00 | Round 9 |
| | Munster v Edinburgh | TBC | 15:00 | 17:00 | Round 9 |
| | Gwent Dragons v Stormers | TBC | 15:00 | 17:00 | Round 9 |
| | Cardiff Blues v Bulls | TBC | 15:00 | 17:00 | Round 9 |
| | Ulster v Leinster | TBC | 15:00 | 17:00 | Round 9 |
| |
| | Sat, 24 December 2022 |
| | Bulls v Stormers | TBC | 15:00 | 17:00 | Round 10 |
| | Edinburgh v Glasgow Warriors | TBC | 15:00 | 17:00 | Round 10 |
| | Ulster v Connacht | TBC | 15:00 | 17:00 | Round 10 |
| | Cardiff Blues v Gwent Dragons | TBC | 15:00 | 17:00 | Round 10 |
| | Scarlets v Ospreys | TBC | 15:00 | 17:00 | Round 10 |
| | Lions v Sharks | TBC | 15:00 | 17:00 | Round 10 |
| | Zebre v Benetton Treviso | TBC | 15:00 | 17:00 | Round 10 |
| | Leinster v Munster | TBC | 15:00 | 17:00 | Round 10 |
| |
| | Sat, 31 December 2022 |
| | Ospreys v Cardiff Blues | TBC | 15:00 | 17:00 | Round 11 |
| | Gwent Dragons v Scarlets | TBC | 15:00 | 17:00 | Round 11 |
| | Glasgow Warriors v Edinburgh | TBC | 15:00 | 17:00 | Round 11 |
| | Lions v Stormers | TBC | 15:00 | 17:00 | Round 11 |
| | Munster v Ulster | TBC | 15:00 | 17:00 | Round 11 |
| | Benetton Treviso v Zebre | TBC | 15:00 | 17:00 | Round 11 |
| | Bulls v Sharks | TBC | 15:00 | 17:00 | Round 11 |
| | Connacht v Leinster | TBC | 15:00 | 17:00 | Round 11 |
| |
| | Sat, 7 January 2023 |
| | Bulls v Gwent Dragons | TBC | 15:00 | 17:00 | Round 12 |
| | Ulster v Benetton Treviso | TBC | 15:00 | 17:00 | Round 12 |
| | Lions v Munster | TBC | 15:00 | 17:00 | Round 12 |
| | Scarlets v Cardiff Blues | TBC | 15:00 | 17:00 | Round 12 |
| | Zebre v Edinburgh | TBC | 15:00 | 17:00 | Round 12 |
| | Stormers v Glasgow Warriors | TBC | 15:00 | 17:00 | Round 12 |
| | Sharks v Connacht | TBC | 15:00 | 17:00 | Round 12 |
| | Leinster v Ospreys | TBC | 15:00 | 17:00 | Round 12 |
| |
| | Sat, 28 January 2023 |
| | Munster v Benetton Treviso | TBC | 15:00 | 17:00 | Round 13 |
| | Lions v Connacht | TBC | 15:00 | 17:00 | Round 13 |
| | Ospreys v Zebre | TBC | 15:00 | 17:00 | Round 13 |
| | Glasgow Warriors v Gwent Dragons | TBC | 15:00 | 17:00 | Round 13 |
| | Stormers v Ulster | TBC | 15:00 | 17:00 | Round 13 |
| | Bulls v Scarlets | TBC | 15:00 | 17:00 | Round 13 |
| | Cardiff Blues v Leinster | TBC | 15:00 | 17:00 | Round 13 |
| | Sharks v Edinburgh | TBC | 15:10 | 17:10 | Round 13 |
| |
| | Fri, 3 February 2023 |
| | Stormers v Sharks | Kings Park Stadium | 17:00 | 19:00 | Round 1 |
| |
| | Sat, 11 February 2023 |
| | Stormers v Lions | TBC | 15:00 | 17:00 | Round 7 |
| |
| | Sat, 18 February 2023 |
| | Connacht v Zebre | TBC | 15:00 | 17:00 | Round 14 |
| | Benetton Treviso v Cardiff Blues | TBC | 15:00 | 17:00 | Round 14 |
| | Edinburgh v Scarlets | TBC | 15:00 | 17:00 | Round 14 |
| | Gwent Dragons v Leinster | TBC | 15:00 | 17:00 | Round 14 |
| | Sharks v Lions | TBC | 15:00 | 17:00 | Round 14 |
| | Ospreys v Munster | TBC | 15:00 | 17:00 | Round 14 |
| | Ulster v Glasgow Warriors | TBC | 15:00 | 17:00 | Round 14 |
| | Stormers v Bulls | TBC | 15:00 | 17:00 | Round 14 |
| |
| | Sat, 4 March 2023 |
| | Zebre v Glasgow Warriors | TBC | 15:00 | 17:00 | Round 15 |
| | Ulster v Cardiff Blues | TBC | 15:00 | 17:00 | Round 15 |
| | Benetton Treviso v Ospreys | TBC | 15:00 | 17:00 | Round 15 |
| | Sharks v Stormers | TBC | 15:00 | 17:00 | Round 15 |
| | Scarlets v Munster | TBC | 15:00 | 17:00 | Round 15 |
| | Leinster v Edinburgh | TBC | 15:00 | 17:00 | Round 15 |
| | Connacht v Gwent Dragons | TBC | 15:00 | 17:00 | Round 15 |
| | Lions v Bulls | TBC | 15:00 | 17:00 | Round 15 |
| |
| | Sat, 25 March 2023 |
| | Lions v Benetton Treviso | TBC | 15:00 | 17:00 | Round 16 |
| | Sharks v Scarlets | TBC | 15:00 | 17:00 | Round 16 |
| | Gwent Dragons v Ospreys | TBC | 15:00 | 17:00 | Round 16 |
| | Bulls v Ulster | TBC | 15:00 | 17:00 | Round 16 |
| | Glasgow Warriors v Munster | TBC | 15:00 | 17:00 | Round 16 |
| | Stormers v Leinster | TBC | 15:00 | 17:00 | Round 16 |
| | Edinburgh v Connacht | TBC | 15:00 | 17:00 | Round 16 |
| | Cardiff Blues v Zebre | TBC | 15:00 | 17:00 | Round 16 |
| |
| | Sat, 15 April 2023 |
| | Benetton Treviso v Sharks | TBC | 15:00 | 17:00 | Round 17 |
| | Zebre v Bulls | TBC | 15:00 | 17:00 | Round 17 |
| | Cardiff Blues v Connacht | TBC | 15:00 | 17:00 | Round 17 |
| | Munster v Stormers | TBC | 15:00 | 17:00 | Round 17 |
| | Scarlets v Glasgow Warriors | TBC | 15:00 | 17:00 | Round 17 |
| | Leinster v Lions | TBC | 15:00 | 17:00 | Round 17 |
| | Ospreys v Edinburgh | TBC | 15:00 | 17:00 | Round 17 |
| | Gwent Dragons v Ulster | TBC | 15:00 | 17:00 | Round 17 |
| |
| | Sat, 22 April 2023 |
| | Edinburgh v Ulster | TBC | 15:00 | 17:00 | Round 18 |
| | Zebre v Lions | TBC | 15:00 | 17:00 | Round 18 |
| | Munster v Sharks | TBC | 15:00 | 17:00 | Round 18 |
| | Connacht v Glasgow Warriors | TBC | 15:00 | 17:00 | Round 18 |
| | Cardiff Blues v Ospreys | TBC | 15:00 | 17:00 | Round 18 |
| | Scarlets v Gwent Dragons | TBC | 15:00 | 17:00 | Round 18 |
| | Leinster v Bulls | TBC | 15:00 | 17:00 | Round 18 |
| | Benetton Treviso v Stormers | TBC | 15:00 | 17:00 | Round 18 |
