| | FIXTURE | VENUE | GMT | LOCAL | POOL |
| | Fri, 9 December 2022 |
| | Montpellier v London Irish | Community Stadium | 20:00 | 22:00 | Round 1 |
| |
| | Sat, 10 December 2022 |
| | Harlequins v Sharks | Kings Park Stadium | 13:00 | 15:00 | Round 1 |
| | Leinster v Racing 92 | Stade Océane, Le Havre | 13:00 | 15:00 | Round 1 |
| | Bordeaux v Gloucester | Kingsholm Stadium | 15:15 | 17:15 | Round 1 |
| | Stormers v Clermont | Stadium Marcel-Michelin | 15:15 | 17:15 | Round 1 |
| | Northampton Saints v La Rochelle | Stade Marcel Deflandre | 17:30 | 19:30 | Round 1 |
| | Lyon v Bulls | Loftus Versfeld | 17:30 | 19:30 | Round 1 |
| | Exeter Chiefs v Castres | Stade Pierre Fabre | 20:00 | 22:00 | Round 1 |
| |
| | Sun, 11 December 2022 |
| | Ulster v Sale Sharks | AJ Bell Stadium | 13:00 | 15:00 | Round 1 |
| | Toulouse v Munster | Thomond Park | 15:15 | 17:15 | Round 1 |
| | Edinburgh v Saracens | StoneX Stadium | 15:15 | 17:15 | Round 1 |
| | Leicester Tigers v Ospreys | Swansea RFC | 17:30 | 19:30 | Round 1 |
| |
| | Fri, 16 December 2022 |
| | Sharks v Bordeaux | Stade Chaban-Delmas | 20:00 | 22:00 | Round 2 |
| | Gloucester v Leinster | RDS Arena | 20:00 | 22:00 | Round 2 |
| |
| | Sat, 17 December 2022 |
| | Castres v Edinburgh | Dam Health Stadium | 13:00 | 15:00 | Round 2 |
| | Bulls v Exeter Chiefs | Sandy Park Stadium | 13:00 | 15:00 | Round 2 |
| | Saracens v Lyon | Matmut Stadium de Gerland | 15:15 | 17:15 | Round 2 |
| | Clermont v Leicester Tigers | Mattioli Woods Welford Road | 15:15 | 17:15 | Round 2 |
| | La Rochelle v Ulster | Kingspan Stadium | 17:30 | 19:30 | Round 2 |
| | London Irish v Stormers | DHL Stadium | 17:30 | 19:30 | Round 2 |
| | Ospreys v Montpellier | GGL Stadium | 20:00 | 22:00 | Round 2 |
| |
| | Sun, 18 December 2022 |
| | Sale Sharks v Toulouse | Franklins Gardens | 13:00 | 15:00 | Round 2 |
| | Racing 92 v Harlequins | Twickenham Stoop | 17:30 | 19:30 | Round 2 |
| |
| | Fri, 13 January 2023 |
| | Leicester Tigers v Clermont | Stadium Marcel-Michelin | 20:00 | 22:00 | Round 3 |
| |
| | Sat, 14 January 2023 |
| | Leinster v Gloucester | Kingsholm Stadium | 13:00 | 15:00 | Round 3 |
| | Toulouse v Sale Sharks | AJ Bell Stadium | 13:00 | 15:00 | Round 3 |
| | Northampton Saints v Munster | Thomond Park | 15:15 | 17:15 | Round 3 |
| | Northampton Saints v Munster | Thomond Park | 15:15 | 17:15 | Round 3 |
| | Bordeaux v Sharks | Kings Park Stadium | 17:15 | 19:15 | Round 3 |
| | Exeter Chiefs v Bulls | Loftus Versfeld | 17:30 | 19:30 | Round 3 |
| | Ulster v La Rochelle | Stade Marcel Deflandre | 17:30 | 19:30 | Round 3 |
| | Lyon v Saracens | StoneX Stadium | 20:00 | 22:00 | Round 3 |
| | Montpellier v Ospreys | Swansea RFC | 20:00 | 22:00 | Round 3 |
| |
| | Sun, 15 January 2023 |
| | Stormers v London Irish | Community Stadium | 13:00 | 15:00 | Round 3 |
| | Edinburgh v Castres | Stade Pierre Fabre | 13:00 | 15:00 | Round 3 |
| | Harlequins v Racing 92 | Paris La Defense Arena | 15:15 | 17:15 | Round 3 |
| |
| | Fri, 20 January 2023 |
| | Ospreys v Leicester Tigers | Mattioli Woods Welford Road | 20:00 | 22:00 | Round 4 |
| | Bulls v Lyon | Matmut Stadium de Gerland | 20:00 | 22:00 | Round 4 |
| |
| | Sat, 21 January 2023 |
| | La Rochelle v Northampton Saints | Franklins Gardens | 13:00 | 15:00 | Round 4 |
| | Sharks v Harlequins | Twickenham | 13:00 | 15:00 | Round 4 |
| | Racing 92 v Leinster | Aviva Stadium | 15:15 | 17:15 | Round 4 |
| | Gloucester v Bordeaux | Stade Chaban-Delmas | 15:15 | 17:15 | Round 4 |
| | Castres v Exeter Chiefs | Sandy Park Stadium | 17:30 | 19:30 | Round 4 |
| | Clermont v Stormers | DHL Stadium | 17:30 | 19:30 | Round 4 |
| | Sale Sharks v Ulster | Kingspan Stadium | 20:00 | 22:00 | Round 4 |
| |
| | Sun, 22 January 2023 |
| | London Irish v Montpellier | GGL Stadium | 13:00 | 15:00 | Round 4 |
| | Munster v Toulouse | Stade Ernest Wallon | 15:15 | 17:15 | Round 4 |
| | Saracens v Edinburgh | Dam Health Stadium | 17:30 | 19:30 | Round 4 |
