| FIXTURE | VENUE | GMT | LOCAL | POOL |
| Fri, 9 September 2022 |
| Bath v Bristol | Ashton Gate | 18:45 | 20:45 | Round 1 |
| Northampton Saints v Sale Sharks | Salford City Stadium | 18:45 | 20:45 | Round 1 |
|
| Sat, 10 September 2022 |
| Worcester Warriors v London Irish | Community Stadium | 14:00 | 16:00 | Round 1 |
| Harlequins v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 1 |
| Leicester Tigers v Exeter Chiefs | Sandy Park Stadium | 18:45 | 20:45 | Round 1 |
|
| Sun, 11 September 2022 |
| Wasps v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 1 |
|
| Fri, 16 September 2022 |
| London Irish v Northampton Saints | Franklins Gardens | 18:45 | 20:45 | Round 2 |
|
| Sat, 17 September 2022 |
| Sale Sharks v Bath | Recreation Ground | 14:00 | 16:00 | Round 2 |
| Saracens v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 2 |
| Newcastle Falcons v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 2 |
| Bristol v Wasps | Coventry Building Society Arena | 14:00 | 16:00 | Round 2 |
|
| Sun, 18 September 2022 |
| Exeter Chiefs v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 2 |
|
| Fri, 23 September 2022 |
| Wasps v Bath | Recreation Ground | 18:45 | 20:45 | Round 3 |
|
| Sat, 24 September 2022 |
| Newcastle Falcons v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 3 |
| Gloucester v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 3 |
| London Irish v Bristol | Ashton Gate | 14:00 | 16:00 | Round 3 |
| Leicester Tigers v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 3 |
|
| Sun, 25 September 2022 |
| Harlequins v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 3 |
|
| Fri, 30 September 2022 |
| Bristol v Newcastle Falcons | Kingston Park | 18:45 | 20:45 | Round 4 |
|
| Sat, 1 October 2022 |
| Worcester Warriors v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 4 |
| Bath v London Irish | Community Stadium | 14:00 | 16:00 | Round 4 |
| Exeter Chiefs v Sale Sharks | Salford City Stadium | 14:00 | 16:00 | Round 4 |
| Leicester Tigers v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 4 |
|
| Sun, 2 October 2022 |
| Northampton Saints v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 4 |
|
| Fri, 7 October 2022 |
| Exeter Chiefs v Bristol | Ashton Gate | 18:45 | 20:45 | Round 5 |
|
| Sat, 8 October 2022 |
| Saracens v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 5 |
| Harlequins v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 5 |
| Sale Sharks v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 5 |
| Gloucester v Bath | Recreation Ground | 14:00 | 16:00 | Round 5 |
|
| Sun, 9 October 2022 |
| Northampton Saints v Wasps | Coventry Building Society Arena | 14:00 | 16:00 | Round 5 |
|
| Sat, 15 October 2022 |
| Wasps v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 6 |
| Bristol v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 6 |
| Newcastle Falcons v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 6 |
| Bath v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 6 |
| London Irish v Sale Sharks | Salford City Stadium | 18:45 | 20:45 | Round 6 |
|
| Sun, 16 October 2022 |
| Leicester Tigers v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 6 |
|
| Fri, 21 October 2022 |
| Gloucester v London Irish | Community Stadium | 18:45 | 20:45 | Round 7 |
|
| Sat, 22 October 2022 |
| Worcester Warriors v Bristol | Ashton Gate | 14:00 | 16:00 | Round 7 |
| Wasps v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 7 |
| Northampton Saints v Bath | Recreation Ground | 14:00 | 16:00 | Round 7 |
| Saracens v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 7 |
|
| Sun, 23 October 2022 |
| Harlequins v Sale Sharks | Salford City Stadium | 14:00 | 16:00 | Round 7 |
|
| Fri, 28 October 2022 |
| Exeter Chiefs v Gloucester | Kingsholm Stadium | 18:45 | 20:45 | Round 8 |
|
| Sat, 29 October 2022 |
| London Irish v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 8 |
| Bristol v Northampton Saints | Franklins Gardens | 14:00 | 16:00 | Round 8 |
| Bath v Worcester Warriors | Sixways | 14:00 | 16:00 | Round 8 |
|
| Sun, 30 October 2022 |
| Sale Sharks v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 8 |
| Newcastle Falcons v Wasps | Coventry Building Society Arena | 14:00 | 16:00 | Round 8 |
|
| Fri, 4 November 2022 |
| Exeter Chiefs v Northampton Saints | Franklins Gardens | 19:45 | 21:45 | Round 9 |
|
| Sat, 5 November 2022 |
| Gloucester v Sale Sharks | Salford City Stadium | 13:00 | 15:00 | Round 9 |
| Worcester Warriors v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 9 |
| Wasps v London Irish | Community Stadium | 14:00 | 16:00 | Round 9 |
| Bath v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 9 |
| Saracens v Bristol | Ashton Gate | 17:00 | 19:00 | Round 9 |
|
| Fri, 11 November 2022 |
| Leicester Tigers v Bath | Recreation Ground | 19:45 | 21:45 | Round 10 |
|
| Sat, 12 November 2022 |
| Newcastle Falcons v Gloucester | Kingsholm Stadium | 15:00 | 17:00 | Round 10 |
| Sale Sharks v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 10 |
| London Irish v Exeter Chiefs | Sandy Park Stadium | 17:00 | 19:00 | Round 10 |
|
| Sun, 13 November 2022 |
| Harlequins v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 10 |
| Northampton Saints v Saracens | Kingston Park | 15:00 | 17:00 | Round 10 |
|
| Sat, 26 November 2022 |
| Exeter Chiefs v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 11 |
| Wasps v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 11 |
| Worcester Warriors v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 11 |
| London Irish v Leicester Tigers | Mattioli Woods Welford Road | 15:00 | 17:00 | Round 11 |
| Bristol v Sale Sharks | Salford City Stadium | 15:00 | 17:00 | Round 11 |
| Gloucester v Harlequins | Twickenham Stoop | 15:00 | 17:00 | Round 11 |
|
| Sat, 3 December 2022 |
| Sale Sharks v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 12 |
| Newcastle Falcons v London Irish | Community Stadium | 15:00 | 17:00 | Round 12 |
| Northampton Saints v Gloucester | Kingsholm Stadium | 15:00 | 17:00 | Round 12 |
| Leicester Tigers v Bristol | Ashton Gate | 15:00 | 17:00 | Round 12 |
| Harlequins v Bath | Recreation Ground | 15:00 | 17:00 | Round 12 |
| Saracens v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 12 |
|
| Sat, 24 December 2022 |
| Saracens v London Irish | Community Stadium | 15:00 | 17:00 | Round 13 |
| Worcester Warriors v Wasps | Coventry Building Society Arena | 15:00 | 17:00 | Round 13 |
| Sale Sharks v Newcastle Falcons | Kingston Park | 15:00 | 17:00 | Round 13 |
| Bristol v Harlequins | Twickenham | 15:00 | 17:00 | Round 13 |
| Gloucester v Leicester Tigers | Mattioli Woods Welford Road | 15:00 | 17:00 | Round 13 |
|
| Sun, 25 December 2022 |
| Bath v Exeter Chiefs | Sandy Park Stadium | 15:00 | 17:00 | Round 13 |
|
| Sat, 31 December 2022 |
| London Irish v Worcester Warriors | Sixways | 15:00 | 17:00 | Round 14 |
| Newcastle Falcons v Bath | Recreation Ground | 15:00 | 17:00 | Round 14 |
| Exeter Chiefs v Saracens | StoneX Stadium | 15:00 | 17:00 | Round 14 |
| Wasps v Bristol | Ashton Gate | 15:00 | 17:00 | Round 14 |
| Leicester Tigers v Sale Sharks | Salford City Stadium | 15:00 | 17:00 | Round 14 |
| Harlequins v Northampton Saints | Franklins Gardens | 15:00 | 17:00 | Round 14 |
|
| Sat, 7 January 2023 |
| Worcester Warriors v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 15 |
| Bristol v London Irish | Community Stadium | 14:00 | 16:00 | Round 15 |
| Northampton Saints v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 15 |
| Bath v Gloucester | Kingsholm Stadium | 14:00 | 16:00 | Round 15 |
| Wasps v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 15 |
| Newcastle Falcons v Saracens | StoneX Stadium | 14:00 | 16:00 | Round 15 |
|
| Sat, 28 January 2023 |
| Gloucester v Exeter Chiefs | Sandy Park Stadium | 14:00 | 16:00 | Round 16 |
| Saracens v Bath | Recreation Ground | 14:00 | 16:00 | Round 16 |
| Northampton Saints v Newcastle Falcons | Kingston Park | 14:00 | 16:00 | Round 16 |
| Sale Sharks v Harlequins | Twickenham Stoop | 14:00 | 16:00 | Round 16 |
| London Irish v Wasps | Coventry Building Society Arena | 14:23 | 16:23 | Round 16 |
| Leicester Tigers v Worcester Warriors | Sixways | 14:24 | 16:24 | Round 16 |
|
| Sat, 4 February 2023 |
| Newcastle Falcons v Bristol | Ashton Gate | 14:04 | 16:04 | Round 17 |
| London Irish v Gloucester | Kingsholm Stadium | 14:26 | 16:26 | Round 17 |
| Harlequins v Leicester Tigers | Mattioli Woods Welford Road | 14:27 | 16:27 | Round 17 |
| Bath v Northampton Saints | Franklins Gardens | 14:28 | 16:28 | Round 17 |
| Worcester Warriors v Sale Sharks | Salford City Stadium | 14:29 | 16:29 | Round 17 |
| Exeter Chiefs v Wasps | Coventry Building Society Arena | 14:30 | 16:30 | Round 17 |
|
| Sat, 11 February 2023 |
| Exeter Chiefs v Bath | Recreation Ground | 14:31 | 16:31 | Round 18 |
| Sale Sharks v London Irish | Community Stadium | 14:32 | 16:32 | Round 18 |
| Leicester Tigers v Newcastle Falcons | Kingston Park | 14:33 | 16:33 | Round 18 |
| Gloucester v Northampton Saints | Franklins Gardens | 14:34 | 16:34 | Round 18 |
| Bristol v Saracens | StoneX Stadium | 14:34 | 16:34 | Round 18 |
| Wasps v Worcester Warriors | Sixways | 14:36 | 16:36 | Round 18 |
|
| Sat, 18 February 2023 |
| Sale Sharks v Exeter Chiefs | Sandy Park Stadium | 14:37 | 16:37 | Round 19 |
| Saracens v Gloucester | Kingsholm Stadium | 14:38 | 16:38 | Round 19 |
| Newcastle Falcons v Harlequins | Twickenham Stoop | 14:38 | 16:38 | Round 19 |
| Bristol v Leicester Tigers | Mattioli Woods Welford Road | 14:39 | 16:39 | Round 19 |
| Bath v Wasps | Coventry Building Society Arena | 14:40 | 16:40 | Round 19 |
| Northampton Saints v Worcester Warriors | Sixways | 14:41 | 16:41 | Round 19 |
|
| Sat, 4 March 2023 |
| London Irish v Bath | Recreation Ground | 14:42 | 16:42 | Round 20 |
| Northampton Saints v Bristol | Ashton Gate | 14:43 | 16:43 | Round 20 |
| Worcester Warriors v Harlequins | Twickenham Stoop | 14:44 | 16:44 | Round 20 |
| Exeter Chiefs v Leicester Tigers | Mattioli Woods Welford Road | 14:44 | 16:44 | Round 20 |
| Gloucester v Newcastle Falcons | Kingston Park | 14:45 | 16:45 | Round 20 |
| Saracens v Sale Sharks | Salford City Stadium | 14:46 | 16:46 | Round 20 |
|
| Sat, 11 March 2023 |
| Bristol v Exeter Chiefs | Sandy Park Stadium | 14:47 | 16:47 | Round 21 |
| Harlequins v Gloucester | Kingsholm Stadium | 14:48 | 16:48 | Round 21 |
| Leicester Tigers v London Irish | Community Stadium | 14:48 | 16:48 | Round 21 |
| Wasps v Northampton Saints | Franklins Gardens | 14:49 | 16:49 | Round 21 |
| Bath v Sale Sharks | Salford City Stadium | 14:49 | 16:49 | Round 21 |
| Worcester Warriors v Saracens | StoneX Stadium | 14:50 | 16:50 | Round 21 |
|
| Sat, 18 March 2023 |
| Bath v Leicester Tigers | Mattioli Woods Welford Road | 14:00 | 16:00 | Round 22 |
| London Irish v Newcastle Falcons | Kingston Park | 14:28 | 16:28 | Round 22 |
| Gloucester v Worcester Warriors | Sixways | 14:44 | 16:44 | Round 22 |
| Saracens v Wasps | Coventry Building Society Arena | 14:45 | 16:45 | Round 22 |
| Sale Sharks v Bristol | Ashton Gate | 14:51 | 16:51 | Round 22 |
| Exeter Chiefs v Harlequins | Twickenham Stoop | 14:52 | 16:52 | Round 22 |
|
| Sat, 25 March 2023 |
| Bristol v Bath | Recreation Ground | 14:56 | 16:56 | Round 23 |
| Newcastle Falcons v Exeter Chiefs | Sandy Park Stadium | 14:57 | 16:57 | Round 23 |
| Leicester Tigers v Gloucester | Kingsholm Stadium | 14:57 | 16:57 | Round 23 |
| Northampton Saints v London Irish | Community Stadium | 14:58 | 16:58 | Round 23 |
| Wasps v Sale Sharks | Salford City Stadium | 14:58 | 16:58 | Round 23 |
| Harlequins v Saracens | Tottenham Hotspur Stadium | 14:59 | 16:59 | Round 23 |
|
| Sat, 15 April 2023 |
| Saracens v Leicester Tigers | Mattioli Woods Welford Road | 14:01 | 16:01 | Round 24 |
| Exeter Chiefs v London Irish | Community Stadium | 14:02 | 16:02 | Round 24 |
| Worcester Warriors v Newcastle Falcons | Kingston Park | 14:02 | 16:02 | Round 24 |
| Sale Sharks v Northampton Saints | Franklins Gardens | 14:03 | 16:03 | Round 24 |
| Gloucester v Wasps | Coventry Building Society Arena | 14:04 | 16:04 | Round 24 |
| Harlequins v Bristol | Ashton Gate | 14:07 | 16:07 | Round 24 |
|
| Sat, 22 April 2023 |
| Northampton Saints v Exeter Chiefs | Sandy Park Stadium | 14:05 | 16:05 | Round 25 |
| Sale Sharks v Gloucester | Kingsholm Stadium | 14:06 | 16:06 | Round 25 |
| Bath v Harlequins | Twickenham | 14:07 | 16:07 | Round 25 |
| Wasps v Newcastle Falcons | Kingston Park | 14:08 | 16:08 | Round 25 |
| London Irish v Saracens | StoneX Stadium | 14:09 | 16:09 | Round 25 |
| Bristol v Worcester Warriors | Sixways | 14:10 | 16:10 | Round 25 |
|
| Sat, 6 May 2023 |
| Worcester Warriors v Bath | Recreation Ground | 14:12 | 16:12 | Round 26 |
| Gloucester v Bristol | Ashton Gate | 14:12 | 16:12 | Round 26 |
| Harlequins v London Irish | Community Stadium | 14:13 | 16:13 | Round 26 |
| Saracens v Northampton Saints | Franklins Gardens | 14:15 | 16:15 | Round 26 |
| Newcastle Falcons v Sale Sharks | Salford City Stadium | 14:15 | 16:15 | Round 26 |
| Leicester Tigers v Wasps | Coventry Building Society Arena | 14:16 | 16:16 | Round 26 |